MULTISCALE POLYMER PROCESSING FOR LIFE SCIENCES
What we do...
The ThieleLab’s competences are in the field of microfluidics, high-resolution additive manufacturing, polymer and organic synthesis, cell-free biosynthesis and cell culturing platforms. Based on 10+ years of experience in microfluidic device design/operation and being founders of the Leibniz Application Laboratory „Additive Manufacturing / 3D- printing“, our focus is on multi-scale polymer processing for evolution of active soft matter. The ThieleLab translates monomer- and macromer-based hydrogel precursors, surfactants and photopolymer formulations into multifunctional, stimuli-sensitive polymer materials via additive manufacturing and microfluidics with feature sizes from a few micrometers to the millimeter-scale and beyond. Our particular strength lies in the design of physicochemically and mechanically tailored hydrogel particles (microgels). The hydrogel’s polymer network allows for tailoring size, shape, porosity, elasticity and compartmentalization and is thus the ideal platform not only for recapitulating cellular functions and mimicking cell scaffolds, but to utilize microgels as tailored building blocks in hierarchical soft matter.
- EU ERC StG: 3DPartForm - 3D-printing of PARTiculate FORMulations utilizing polymer microparticle-based voxels (2020-2025),
- VW Change of Course: Cell-free enzymatic functionalization of synthetic polymers (2020-2023),
- DFG RTG 1865: Hydrogel-based Microsystems (2018-2022)
- Y. Li, M. J. Männel, N. Hauck, H. P. Patel, G. K. Auernhammer, S. Chae, A. Fery, J. Li, J. Thiele: „Embedment of quantum dots and biomolecules in an in-situ formed dipeptide hydrogel using microfluidics“, Angew. Chem. Int. Ed. 2021, 60, 6724.
- T. Heida, T. Köhler, A. Kaufmann, M. J. Männel, J. Thiele: „Gene expression in bifunctional hyaluronan hydrogel particles: A strategy for in situ immobilization and purification of His-tagged proteins“, ChemSystemsChem 2020, 2(3), e1900058.
- J. W. Neubauer, N. Hauck, M. J. Männel, A. Fery, J. Thiele: “Mechanoresponsive hydrogel particles as a platform for 3D-force sensing”, ACS Appl. Mater. Interfaces 2019, 11(29), 26307.
- M. J. Männel, L. Selzer, R. Bernhardt, J. Thiele: “Optimizing process parameters in commercial µ–stereolithography for forming emulsions and polymer microparticles in non–planar MF devices”, Adv. Mater. Technol. 2019, 4, 1800408.
- J. Thiele: “Polymer material design by microfluidics inspired by cell biology and cell-free biotechnology”, Macromol. Chem. Phys. 2017, 218, 1600429.
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