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Dr. Uwe Freudenberg

Institute of Biofunctional Polymer Materials
+49 351 4658 408/ 573 +49 351 4658 533

Personal data

  • 2010-present: Speaker of the research area Matrix Engineering
  • 2007-present: Responsible for the division Biohybrid-Hydrogels at the Institut Biofunktionelle Polymermaterialien of the IPF
  • 2007: Doctoral thesis (Dr.-Ing.) in material science, Faculty of Mechanical Science and Engineering, Technische Universität Dresden
  • 2003-present: Scientific co-worker at Leibniz-Institut für Polymerforschung Dresden e.V. (IPF)/ Institut Biofunktionelle Polymermaterialien
  • 2001-2003: Process engineer, Advanced Micro Devices Saxony LLC & Co. KG, Dresden

Fields of work

  • multifunctional polymer materials for biomedical applications with special emphasis on glycosaminoglycan(GAG)-based hydrogels
  • synthetic and biohybrid matrices for tissue engineering applications
  • cell-instructive polymer coatings
  • cellulose thin films

Publications

  • Maitz, M.F. ; Freudenberg, U. ; Tsurkan, M. ; Fischer, M. ; Beyrich, T. ; Werner, C. Bio-responsive polymer hydrogels homeostatically regulate blood coagulation more Nature Communications 4 (2013) 7 Seiten [OPEN]
  • Krüger, K. ; Terne, C. ; Werner, C. ; Freudenberg, U. ; Jankowski, V. ; Zidek, W. ; Jankowski, J. Characterization of polymer membranes by MALDI-mass-spectrometric imaging techniques more Analytical Chemistry 85 (2013) S, 4998-5004
  • Tsurkan, M. ; Chwalek, K. ; Prokoph, S. ; Zieris, A. ; Levental, K. ; Freudenberg, U. ; Werner, C. Defined polymer-peptide conjugates to form cell-instructive star PEG-heparin matrices in situ more Advanced Materials 25 (2013) 2606-2610
  • Tsurkan, M. ; Hauser, P. V. ; Zieris, A. ; Carvalhosa, R. ; Bussolati, B. ; Freudenberg, U. ; Gamussi, G. ; Werner, C. Growth factor delivery from hydrogel particle aggregates to promote tubular regeneration after acute kidney injury more Journal of Controlled Release 167 (2013) 248-255
  • Wieduwild, R. ; Tsurkan, M. ; Chwalek, K. ; Murawala, P. ; Nowak, M. ; Freudenberg, U. ; Neinhuis, C. ; Werner, C. ; Zhang, Y. Minimal peptide motif for non-covalent peptide-heparin hydrogels more Journal of the American Chemical Society 135 (2013) 2919-2922
  • Zieris, A. ; Werner, C. ; Prokoph, S. ; Levental, K. ; Welzel, P. ; Chwalek, K. ; Schneider, K. ; Freudenberg, U. Sustainable growth factor delivery through affinity-based adsorption to star PEG-heparin hydrogels more American Chemical Society 1120 (2012) Chapter 24, 525-541
  • Zimmermann, R. ; Bartsch, S. ; Freudenberg, U. ; Werner, C. Electrokinetic analysis to reveal composition and structure of biohybrid hydrogels more Analytical Chemistry 84 (2012) 9592-9595
  • Welzel, P. ; Grimmer, M. ; Renneberg, C. ; Naujox, L. ; Zschoche, St. ; Freudenberg, U. ; Werner, C. Macroporous starPEG-heparin cryogels more Biomacromolecules 13 (2012) 2349-2358
  • Baumann, L. ; Prokoph, S. ; Gabriel, C. ; Freudenberg, U. ; Werner, C. ; Beck-Sickinger, A. G. A novel, biased-like SDF-1 derivative acts synergistically with star PEG -based heparin hydrogels and improves eEPC migration in vitro more Journal of Controlled Release 162 (2012) 68–75
  • Prokoph, S. ; Chavakis, E. ; Levental, K. ; Zieris, A. ; Freudenberg, U. ; Dimmeler, S. ; Werner, C. Sustained delivery of SDF-1a from heparin-based hydrogels to attract circulating pro-angiogenic cells more Biomaterials 33 (2012) 4792-4800
  • Freudenberg, U.; Sommer, J.-U.; Levental, K.; Welzel, P; Zieris, A.; Chwalek, K.; Schneider, K.; Prokoph, S.; Prewitz, M.; Dockhorn, R.; Werner, C. Using Mean Field Theory to Guide Biofunctional Materials Design more Advanced Functional Materials 22 (2012) 1391-1398
  • Chwalek, K. ; Levental, K. ; Tsurkan, M. ; Zieris, A. ; Freudenberg, U. ; Werner, C. Two-tier hydrogel degradation to boost endothelial cell morphogenesis more Biomaterials 32 (2011) 9649-9657
  • Zieris, A. ; Chwalek, K. ; Prokoph, S. ; Levental, K. ; Welzel, P. ; Freudenberg, U. ; Werner, C. Dual independent delivery of pro-angiogenic growth factors from starPEG-heparin hydrogels more Journal of Controlled Release 156 (2011) 28-36
  • Welzel, P. ; Prokoph, S. ; Zieris, A. ; Grimmer, M. ; Zschoche, St. ; Freudenberg, U. ; Werner, C. Modulating biofunctional starPEG heparin hydrogels by varying size and ratio of the constituents more Polymers [Open Access] 3 (2011) 602-620
  • Sommer, J.-U. ; Dockhorn, R. ; Welzel, P. ; Freudenberg, U. ; Werner, C. Swelling equilibrium of a binary polymer gel more Macromolecules 44 (2011) 981–986
  • Zieris, A. ; Prokoph, S. ; Levental, K. ; Welzel, P. ; Grimmer, M. ; Freudenberg, U. ; Werner, C. FGF-2 and VEGF functionalization of starPEG-heparin hydrogels to modulate biomolecular and physical cues of angiogenesis more Biomaterials 31 (2010) 7985-7994
  • Tsurkan, M. ; Chwalek, K. ; Levental, K. ; Freudenberg, U. ; Werner, C. Modular starPEG-heparin gels with bifunctional peptide linkers more Macromolecular Rapid Communications 31 (2010) 1529-1533
  • Müller, Y. ; Tot, I. ; Potthast, A. ; Rosenau, T. ; Zimmermann, R. ; Eichhorn, K.-J. ; Nitschke, C. ; Scherr, G. ; Freudenberg, U. ; Werner, C. The impact of esterification reactions on physical properties of cellulose thin films more Soft Matter 6 (2010) 3680-3684
  • Zimmermann, R. ; Freudenberg, U. ; Schweiß, R. ; Küttner, D. ; Werner, C. Hydroxide and hydronium ion adsorption - A survey more Current Opinion in Colloid and Interface Science 15 (2010) 196-202
  • Zieris, A. ; Prokoph, S. ; Welzel, P. ; Grimmer, M. ; Levental, K. ; Panyanuwat, W. ; Freudenberg, U. ; Werner, C. Analytical approaches to uptake and release of hydrogel-associated FGF-2 more Journal of Materials Science : Materials in Medicine 21 (2010) 915-923
  • Tsurkan, M. ; Levental, K. ; Freudenberg, U. ; Werner, C. Enzymatically degradable heparin-polyethylene glycol gels with controlled mechanical properties more Chemical Communications 46 (2010) 1141-1143
  • Lanfer, B. ; Hermann, A. ; Kirsch, M. ; Freudenberg, U. ; Reuner, U. ; Werner, C. ; Storch, A. Directed growth of adult human white matter stem cell-derived neurons on aligned fibrillar collagen more Tissue Engineering A 16 (2010) 1103-1113
  • Grombe, R. ; Gouzy, M.-F. ; Freudenberg, U. ; Pompe, T. ; Zschoche, St. ; Simon, F. ; Eichhorn, K.-J. ; Janke, A. ; Voit, B. ; Werner, C. Sulfated cellulose thin films with antithrombin affinity more eXPRESS Polymer Letters 3 (2009) 733-742
  • Welzel, P. ; Nitschke, M. ; Freudenberg, U. ; Zieris, A. ; Götze, T. ; Valtink, M. ; Engelmann, K. ; Werner, C. : Polymer Hydrogels to Enable New Medical Therapies more Springer 6 (2009) 249-266
  • Lanfer, B. ; Seib, P. ; Freudenberg, U. ; Stamov, D. ; Bley, Th. ; Bornhäuser, M. ; Werner, C. The growth and differentiation of mesemchymal stem and progenitor cells cultured on aligned collagen matrices more Biomaterials 30 (2009) 5950-5958