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Dr. Uwe Freudenberg

Institute of Biofunctional Polymer Materials
+49 351 4658 408/ 573 +49 351 4658 533

Personal data

  • 2010-present: Speaker of the research area Matrix Engineering
  • 2007-present: Responsible for the division Biohybrid-Hydrogels at the Institut Biofunktionelle Polymermaterialien of the IPF
  • 2007: Doctoral thesis (Dr.-Ing.) in material science, Faculty of Mechanical Science and Engineering, Technische Universität Dresden
  • 2003-present: Scientific co-worker at Leibniz-Institut für Polymerforschung Dresden e.V. (IPF)/ Institut Biofunktionelle Polymermaterialien
  • 2001-2003: Process engineer, Advanced Micro Devices Saxony LLC & Co. KG, Dresden

Fields of work

  • multifunctional polymer materials for biomedical applications with special emphasis on glycosaminoglycan(GAG)-based hydrogels
  • synthetic and biohybrid matrices for tissue engineering applications
  • cell-instructive polymer coatings
  • cellulose thin films

Publications

  • Husman, D. ; Welzel, P. ; Vogler, S. ; Bray, L. ; Träber, N. ; Friedrichs, J. ; Körber, V. ; Tsurkan, M. ; Freudenberg, U. ; Thiele, J. ; Werner, C. Multiphasic microgel-in-gel materials to recapitulate cellular mesoevironments in vitro more Biomaterials Science 2019 (2019) Advance Article
  • Sievers, J. ; Zschoche, St. ; Dockhorn, R. ; Friedrichs, J. ; Werner, C. ; Freudenberg, U. Temperature-Induced mechanomodulation of interpenetrating networks of star poly(ethylene glycol)-heparin and poly(N-isopropylacrylamide) more ACS Applied Materials & Interfaces 11 (2019) 41862-41874
  • Spiller, S. ; Panitz, N. ; Limasale, Y. D. P. ; Atallah, P. ; Schirmer, L. ; Bellmann-Sickert, K. ; Blaszczyk, J. ; Koehling, S. ; Freudenberg, U. ; Rademann, J. ; Werner, C. ; Beck-Sickinger, A. G. Modulation of Human CXCL12 Binding Properties to Glycosaminoglycans To Enhance Chemotactic Gradients more ACS Biomaterials Science & Engineering 5 (2019) 5128-5138
  • Taubenberger, A. ; Girardo, S. ; Träber, N. ; Fischer-Friedrich, E. ; Kräter, M. ; Wagner, K. ; Kurth, T. ; Richter, I. ; Binner, M. ; Hahn, D. ; Freudenberg, U. ; Werner, C. ; Guck, J. 3D microenvironment stiffness regulates tumor spheroid growth and mechanics via p21 and ROCK more Advanced Biosystems 3 (2019) 1900128
  • Freudenberg, U. ; Atallah, P. ; Limasale, Y. D. P. ; Werner, C. Charge-tuning of glycosaminoglycan-based hydrogels to program cytokine sequestration more Faraday Discussions 2019 (2019) Accepted Manuscript
  • Celikkaya, H. ; Cosacak, M. I. ; Papadimitriou, C. ; Popova, H. ; Bhattarai, P. ; Biswas, S. ; Siddiqui, T. ; Wistorf, S. ; Nevado-Alcalde, I. ; Naumann, L. ; Mashkaryan, V. ; Brandt, K. ; Freudenberg, U. ; Werner, C. ; Kizil, C. GATA3 promotes the neural progenitor state but not neurogenesis in 3D traumatic injury model of primary human cortical astrocytes more Frontiers in Cellular Neuroscience 13 (2019) Article Number: 23
  • Kunisch, E. ; Knauf, A.-K. ; Hesse, E. ; Freudenberg, U. ; Werner, C. ; Bothe, F. ; Diederichs, S. ; Richter, W. StarPEG/heparin-hydrogel based in vivo engineering of stable bizonal cartilage with a calcified bottom layer more Biofabrication 11 (2018) ID015001
  • Atallah, P. ; Schirmer, L. ; Tsurkan, M. ; Limasale, Y. D. P. ; Zimmermann, R. ; Werner, C. ; Freudenberg, U. In situ-forming, cell-instructive hydrogels based on glycosaminoglycans with varied sulfation patterns more Biomaterials 181 (2018) 227-239
  • Papadimitriou, C. ; Celikkaya, H. ; Cosacak, M. I. ; Mashkaryan, V. ; Bray, L. ; Bhattarai, P. ; Brandt, K. ; Hollak, H. ; Chen, X. ; He, S. ; Antos, C. L. ; Lin, W. ; Thomas, A. K. ; Dahlina, A. B. ; Kurth, T. ; Friedrichs, J. ; Zhang, Y. ; Freudenberg, 3D culture method for alzheimers disease modeling reveals interleukin-4 rescues A beta 42-induced Loss of human neural stem cell plasticity more Developmental Cell 46 (2018) 85-101
  • Vogler, S. ; Prokoph, S. ; Freudenberg, U. ; Binner, M. ; Tsurkan, M. ; Werner, C. ; Kempermann, G. Defined geldrop cultures maintain neural precursor cells more Scientific Reports 8 (2018) ID8433
  • Lohmann, N. ; Schirmer, L. ; Atallah, P. ; Wandel, E. ; Ferrer, R. A. ; Werner, C. ; Simon, J. C. ; Franz, S. ; Freudenberg, U. Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice more Experimental Dermatology 27 (2018) E18-E19, P0043
  • Hesse, E. ; Freudenberg, U. ; Niemietz, T. ; Greth, C. ; Weisser, M. ; Hagmann, S. ; Binner, M. ; Werner, C. ; Richter, W. Peptide-functionalized starPEG/heparin hydrogels direct mitogenicity, cell morphology and cartilage matrix distribution in vitro and in vivo more Journal of Tissue Engineering and Regenerative Medicine 12 (2018) 229-239
  • Bray, L. ; Binner, M. ; Freudenberg, U. ; Werner, C. Hydrogel-based in vitro models of tumor angiogenesis more Humana Press 2017 (2017) 39-63
  • Müller, E. ; Werner, C. ; Freudenberg, U. Solvent- assisted micromolding of biohybrid hydrogels to maintain human hematopoietic stem and progenitor cells ex vivo more Advanced Materials 29 (2017) ID1703489
  • Gvaramia, D. ; Müller, E. ; Müller, K. ; Atallah, P. ; Tsurkan, M. ; Freudenberg, U. ; Bornhäuser, M. ; Werner, C. Combined influence of biophysical and biochemical cues on maintenance and proliferation of hematopoietic stem cells more Biomaterials 138 (2017) 108-117
  • Maitz, M.F. ; Zitzmann, J. ; Hanke, J. ; Renneberg, C. ; Tsurkan, M. ; Sperling, C. ; Freudenberg, U. ; Werner, C. Adaptive release of heparin from anticoagulant hydrogels triggered by different blood coagulation factors more Biomaterials 135 (2017) 53-61
  • Weber, H. ; Tsurkan, M. ; Magno, V. ; Freudenberg, U. ; Werner, C. Heparin-based hydrogels induce human renal tubulogenesis in vitro more Acta Biomaterialia 57 (2017) 59-69
  • Müller, E. ; Pompe, T. ; Freudenberg, U. ; Werner, C. Matrix growth factors and surface ligand presentation more Elsevier 2017 (2017) Chapter 14, 251-231
  • Lohmann, N.; Schirmer, L.; Atallah, P.; Wandel, E.; Ferrer, RA.; Werner, C.; Simon, JC.; Franz, S.; Freudenberg, U. Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice more Science Translational Medicine 9 (2017) eaai9044
  • Schlötzer-Schrehardt, U. ; Freudenberg, U. ; Kruse, F. E. The emerging technology of tissue engineering more Der Ophthalmologe 114 (2017) 327-340
  • Schlötzer-Schrehardt, U. ; Freudenberg, U. ; Kruse, F. E. Zukunftstechnologie Tissue-Engineering more Ophthalmologe 114 (2017) 327-340
  • Aliperta, R. ; Welzel, P. ; Bergmann, R. ; Freudenberg, U. ; Berndt, N. ; Feldmann, A. ; Arndt, C. ; Koristka, S. ; Stanzione, M. ; Cartellieri, M. ; Ehninger, A. ; Ehninger, G. ; Werner, C. ; Pietzsch, J. ; Steinbach, J. ; Bornhäuser, M. ; Bachmann, M. Cryogel-supported stem cell factory for customized sustained release of bispecific antibodies for cancer immunotherapy more Scientific Reports 7 (2017) Art.No. 42855
  • Nowak, M. ; Freudenberg, U. ; Tsurkan, M. ; Werner, C. ; Levental, K. Modular GAG-matrices to promote mammary epithelial morphogenesis in vitro more Biomaterials 112 (2017) 20-30
  • Schirmer, L. ; Atallah, P. ; Werner, C. ; Freudenberg, U. StarPEG-heparinhydrogels to protect and sustainably deliver IL-4 more Advanced Healthcare Materials 5 (2016) 3157-3164
  • Zimmermann, R. ; Müller, Y. ; Freudenberg, U. ; Jehnichen, D. ; Potthast, A. ; Rosenau, T. ; Werner, C. Oxidation and structural changes in NMMO-regenerated cellulose films more Cellulose 23 (2016) 3535-3541