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Dr. Uwe Freudenberg

Institute of Biofunctional Polymer Materials
+49 351 4658 408/ 573 +49 351 4658 533

Personal data

  • 2010-present: Speaker of the research area Matrix Engineering
  • 2007-present: Responsible for the division Biohybrid-Hydrogels at the Institut Biofunktionelle Polymermaterialien of the IPF
  • 2007: Doctoral thesis (Dr.-Ing.) in material science, Faculty of Mechanical Science and Engineering, Technische Universität Dresden
  • 2003-present: Scientific co-worker at Leibniz-Institut für Polymerforschung Dresden e.V. (IPF)/ Institut Biofunktionelle Polymermaterialien
  • 2001-2003: Process engineer, Advanced Micro Devices Saxony LLC & Co. KG, Dresden

Fields of work

  • multifunctional polymer materials for biomedical applications with special emphasis on glycosaminoglycan(GAG)-based hydrogels
  • synthetic and biohybrid matrices for tissue engineering applications
  • cell-instructive polymer coatings
  • cellulose thin films

Publications

  • Müller, E. ; Werner, C. ; Freudenberg, U. Solvent- assisted micromolding of biohybrid hydrogels to maintain human hematopoietic stem and progenitor cells ex vivo more Advanced Materials 29 (2017) ID1703489
  • Gvaramia, D. ; Müller, E. ; Müller, K. ; Atallah, P. ; Tsurkan, M. ; Freudenberg, U. ; Bornhäuser, M. ; Werner, C. Combined influence of biophysical and biochemical cues on maintenance and proliferation of hematopoietic stem cells more Biomaterials 138 (2017) 108-117
  • Maitz, M.F. ; Zitzmann, J. ; Hanke, J. ; Renneberg, C. ; Tsurkan, M. ; Sperling, C. ; Freudenberg, U. ; Werner, C. Adaptive release of heparin from anticoagulant hydrogels triggered by different blood coagulation factors more Biomaterials 135 (2017) 53-61
  • Weber, H. ; Tsurkan, M. ; Magno, V. ; Freudenberg, U. ; Werner, C. Heparin-based hydrogels induce human renal tubulogenesis in vitro more Acta Biomaterialia 57 (2017) 59-69
  • Müller, E. ; Pompe, T. ; Freudenberg, U. ; Werner, C. Matrix growth factors and surface ligand presentation more Elsevier 2017 (2017) Chapter 14, 251-231
  • Lohmann, N.; Schirmer, L.; Atallah, P.; Wandel, E.; Ferrer, RA.; Werner, C.; Simon, JC.; Franz, S.; Freudenberg, U. Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice more Science Translational Medicine 9 (2017) eaai9044
  • Schlötzer-Schrehardt, U. ; Freudenberg, U. ; Kruse, F. E. The emerging technology of tissue engineering more Der Ophthalmologe 114 (2017) 327-340
  • Schlötzer-Schrehardt, U. ; Freudenberg, U. ; Kruse, F. E. Zukunftstechnologie Tissue-Engineering more Ophthalmologe 114 (2017) 327-340
  • Aliperta, R. ; Welzel, P. ; Bergmann, R. ; Freudenberg, U. ; Berndt, N. ; Feldmann, A. ; Arndt, C. ; Koristka, S. ; Stanzione, M. ; Cartellieri, M. ; Ehninger, A. ; Ehninger, G. ; Werner, C. ; Pietzsch, J. ; Steinbach, J. ; Bornhäuser, M. ; Bachmann, M. Cryogel-supported stem cell factory for customized sustained release of bispecific antibodies for cancer immunotherapy more Scientific Reports 7 (2017) Art.No. 42855
  • Nowak, M. ; Freudenberg, U. ; Tsurkan, M. ; Werner, C. ; Levental, K. Modular GAG-matrices to promote mammary epithelial morphogenesis in vitro more Biomaterials 112 (2017) 20-30
  • Schirmer, L. ; Atallah, P. ; Werner, C. ; Freudenberg, U. StarPEG-heparinhydrogels to protect and sustainably deliver IL-4 more Advanced Healthcare Materials 5 (2016) 3157-3164
  • Zimmermann, R. ; Müller, Y. ; Freudenberg, U. ; Jehnichen, D. ; Potthast, A. ; Rosenau, T. ; Werner, C. Oxidation and structural changes in NMMO-regenerated cellulose films more Cellulose 23 (2016) 3535-3541
  • Freudenberg, U. ; Liang, Y. ; Kiick, K. ; Werner, C. Glycosaminoglycan-based biohybrid hydrogels: A sweet and smart choice for multifunctional biomaterials more Advanced Materials 28 (2016) 8861-8891
  • Seib, P. ; Tsurkan, M. ; Freudenberg, U. ; Kaplan, D. L. ; Werner, C. Heparin-modified polyethylene glycol microparticle aggregates for focal cancer chemotherapy more ACS Biomaterials Science & Engineering 2 (2016) 2287-2293
  • Borg, D. ; Welzel, P. ; Grimmer, M. ; Friedrichs, J. ; Weigelt, M. ; Wilhelm, C. ; Prewitz, M. ; Stißel, A. ; Hommel, A. ; Kurth, T. ; Freudenberg, U. ; Bonifacio, E. ; Werner, C. Macroporous biohybrid cryogels for co-housing pancreatic islets with mesenchymal stromal cells more Acta Biomaterialia 44 (2016) 178-187
  • Zimmermann, R. ; Friedrichs, J. ; Lanfer, B. ; Freudenberg, U. ; Werner, C. Aligned fibrillar collagen matrices more Wiley 1 (2016) Chapter 27, 340-354
  • Dhawan, A. ; von Bonin, M. ; Bray, L. ; Freudenberg, U. ; Bejestani, E. P. ; Werner, C. ; Hofbauer, L. C. ; Wobus, M. ; Bornhäuser, M. Functional interference in the bone marrow microenvironment by disseminated breast cancer cells more Stem Cells 34 (2016) 2224–2235
  • Taubenberger, A. ; Bray, L. ; Haller, B. ; Shaposhnykov, A. ; Binner, M. ; Freudenberg, U. ; Guck, J. ; Werner, C. 3D extracellular matrix interactions modulate tumour cell growth, invasion and angiogenesis in engineered tumour microenvironments more Acta Biomaterialia 36 (2016) 73-85
  • Lohmann, N. ; Schirmer, L. ; Wandel, E. ; Atallah, P. ; Forstreuter, I. ; Ferrer, R. A. ; Freudenberg, U. ; Werner, C. ; Simon, J. C. ; Franz, S. Immunomodulatory potential of starPEG heparin hydrogels on wound healing associated chemokines more Experimental Dermatology 25 (2016) E8
  • Freudenberg, U. ; Zieris, A. ; Chwalek, K. ; Tsurkan, M. ; Maitz, M.F. ; Atallah, P. ; Levental, K. ; Eming, S. A. ; Werner, C. Heparin desulfation modulates VEGF release and angiogenesis in diabetic wounds more Journal of Controlled Release 220 (2015) 79-88
  • Newland, B. ; Welzel, P. ; Newland, H. ; Renneberg, C. ; Kolar, P. ; Tsurkan, M. ; Rosser, A. ; Freudenberg, U. ; Werner, C. Tackling cell transplantation anoikis: An injectable, shape memory cryogel microcarrier platform material for stem cell and neuronal cell growth more Small 11 (2015) 5047-5053
  • Schurig, K. ; Werner, C. ; Zieris, A. ; Hermann, A. ; Freudenberg, U. ; Heidel, S. ; Grimmer, M. ; Storch, A. Neurotropic growth factors and glycosaminoglycan based matrices to induce dopaminergic tissue formation more Biomaterials 67 (2015) 205-213
  • Watarai, A. ; Schirmer, L. ; Thönes, S. ; Freudenberg, U. ; Werner, C. ; Simon, J. C. ; Anderegg, U. TGFß functionalized starPEG-heparin hydrogels modulate human dermal fibroblast growth and differentiation more Acta Biomaterialia 25 (2015) 65-75
  • Fischer, M. ; Vahdatzadeh, M. ; Konradi, R. ; Friedrichs, J. ; Maitz, M.F. ; Freudenberg, U. ; Werner, C. Multilayer hydrogel coatings to combine hemocompatibility and antimicrobial activity more Biomaterials 56 (2015) 198-205
  • Bray, L. ; Binner, M. ; Holzheu, A. ; Friedrichs, J. ; Freudenberg, U. ; Hutmacher, D. W. ; Werner, C. Multi-parametric hydrogels support 3D in vitro bioengineered microenvironment models of tumour angiogenesis more Biomaterials 53 (2015) 609-620