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Dr. Uwe Freudenberg

Institute of Biofunctional Polymer Materials
+49 351 4658 408/ 573 +49 351 4658 533

Personal data

  • 2010-present: Speaker of the research area Matrix Engineering
  • 2007-present: Responsible for the division Biohybrid-Hydrogels at the Institut Biofunktionelle Polymermaterialien of the IPF
  • 2007: Doctoral thesis (Dr.-Ing.) in material science, Faculty of Mechanical Science and Engineering, Technische Universität Dresden
  • 2003-present: Scientific co-worker at Leibniz-Institut für Polymerforschung Dresden e.V. (IPF)/ Institut Biofunktionelle Polymermaterialien
  • 2001-2003: Process engineer, Advanced Micro Devices Saxony LLC & Co. KG, Dresden

Fields of work

  • multifunctional polymer materials for biomedical applications with special emphasis on glycosaminoglycan(GAG)-based hydrogels
  • synthetic and biohybrid matrices for tissue engineering applications
  • cell-instructive polymer coatings
  • cellulose thin films

Publications

  • Zimmermann, R. ; Nitschke, M. ; Magno, V. ; Freudenberg, U. ; Sockel, K. ; Stölzel, F. ; Wobus, M. ; Platzbecker, U. ; Werner, C. Discriminant principal component analysis of ToF-SIMS spectra for deciphering compositional differences of MSC-secreted extracellular matrices more Small Methods 7 (2023) 2201157
  • Silva, D. ; Schirmer, L. ; Pinho, T. S. ; Atallah, P. ; Cibrão, J. R. ; Lima, R. ; Afonso, J. ; B-Antunes, S. ; Marques, C. R. ; Dourado, J. ; Freudenberg, U. ; Sousa, R. A. ; Werner, C. ; Salgado, A. J. Sustained release of human adipose tissue stem cell secretome from star-shaped poly(ethylene glycol) glycosaminoglycan hydrogels promotes motor improvements after complete transection in spinal cord injury rat model more Advanced Healthcare Materials (2023) early view
  • Siddiqui, T. ; Celikkaya, H. ; Atasavum, Z.T. ; Popova, S. ; Freudenberg, U. ; Werner, C. ; Kizil, C. Three-dimensional biohybrid starPEG-heparin hydrogel cultures for modeling human neuronal development and Alzheimer´s disease pathology more Humana Press (2022) 159-170
  • Wang, R. ; Schirmer, L. ; Wieduwilt, T. ; Förster, R. ; Schmidt, M. ; Freudenberg, U. ; Werner, C. ; Fery, A. ; Rossner, C. Colorimetric biosensors based on polymer/gold hybrid nanoparticles: topological effects of the polymer coating more Langmuir 38 (2022) 12325-12332
  • Kühn, S. ; Freyse, J. ; Attalah, P. ; Rademann, J. ; Freudenberg, U. ; Werner, C. Tuning the network charge of biohybrid hydrogel matrices to modulate the release of SDF-1 more Biological Chemistry 402 (2021) 1453-1464
  • Hahn, D. ; Sonntag, J. M. ; Lück, S. ; Maitz, M.F. ; Freudenberg, U. ; Jordan, R. ; Werner, C. Poly(2-alkyl-2-oxazoline)-heparin hydrogels - expanding the physicochemical parameter space of biohybrid materials more Advanced Healthcare Materials 10 (2021) 2101327
  • Schirmer, L. ; Freudenberg, U. ; Werner, C. Chemokin-bindende Wundauflagen - neue Optionen zur Behandlung chronischer Wunden more Spitzenforschung in der onkologischen Dermatologie - Innovationen und Auszeichnungen 2021 (2021) 22-32
  • Ruland, A. ; Schenker, S. ; Schirmer, L. ; Friedrichs, J. ; Meinhardt, A. ; Schwartz, V. B. ; Kaiser, N. ; Konradi, R. ; MacDonald, W. ; Helmecke, T. ; Sikosana, M. ; Valtin, J. ; Hahn, D. ; Renner, L. ; Werner, C. ; Freudenberg, U. Amphiphilic copolymers for versatile, facile, and in situ tunable surface biofunctionalization more Advanced Materials 33 (2021) 2102489
  • Schirmer, L. ; Atallah, P. ; Freudenberg, U. ; Werner, C. Chemokine-capturing wound contact layer rescues dermal healing more Advanced Science 8 (2021) 2100293
  • Millican, J. ; Bittrich, E. ; Caspari, A. ; Pöschel, K. ; Drechsler, A. ; Freudenberg, U. ; Ryan, T. G. ; Thompson, R. L. ; Pospiech, D. ; Hutchings, L. Synthesis and characterisation of a mussel-inspired hydrogel film coating for biosensors more European Polymer Journal 153 (2021) 110503
  • Newland, B. ; Newland, H. ; Lorenzi, F. ; Eigel, D. ; Welzel, P. ; Fischer, D. ; Wang, W. ; Freudenberg, U. ; Rosser, A. ; Werner, C. Injectable glycosaminoglycan-based cryogels from well-defined microscale templates for local growth factor delivery more ACS Chemical Neuroscience 12 (2021) 1178-1188
  • Walkowiak, J.J. ; Ballauff, M. ; Zimmermann, R. ; Freudenberg, U. ; Werner, C. Thermodynamic Analysis of the Interaction of Heparin with Lysozyme more Biomacromolecules 21 (2020) 4615-4625
  • Limasale, Y. D. P. ; Atallah, P. ; Werner, C. ; Freudenberg, U. ; Zimmermann, R. Tuning the local availability of VEGF within glycosaminoglycan-based hydrogels to modulate vascular endothelial cell morphogenesis more Advanced Functional Materials 30 (2020) 2000068
  • Schirmer, L. ; Chwalek, K. ; Tsurkan, M. ; Freudenberg, U. ; Werner, C. Glycosaminoglycan-based hydrogels with programmable host reactions more Biomaterials 228 (2020) 119557
  • Husman, D. ; Welzel, P. ; Vogler, S. ; Bray, L. ; Träber, N. ; Friedrichs, J. ; Körber, V. ; Tsurkan, M. ; Freudenberg, U. ; Thiele, J. ; Werner, C. Multiphasic microgel-in-gel materials to recapitulate cellular mesoevironments in vitro more Biomaterials Science 2020 (2020) 101-108
  • Sievers, J. ; Zschoche, St. ; Dockhorn, R. ; Friedrichs, J. ; Werner, C. ; Freudenberg, U. Temperature-Induced mechanomodulation of interpenetrating networks of star poly(ethylene glycol)-heparin and poly(N-isopropylacrylamide) more ACS Applied Materials & Interfaces 11 (2019) 41862-41874
  • Spiller, S. ; Panitz, N. ; Limasale, Y. D. P. ; Atallah, P. ; Schirmer, L. ; Bellmann-Sickert, K. ; Blaszczyk, J. ; Koehling, S. ; Freudenberg, U. ; Rademann, J. ; Werner, C. ; Beck-Sickinger, A. G. Modulation of Human CXCL12 Binding Properties to Glycosaminoglycans To Enhance Chemotactic Gradients more ACS Biomaterials Science & Engineering 5 (2019) 5128-5138
  • Taubenberger, A. ; Girardo, S. ; Träber, N. ; Fischer-Friedrich, E. ; Kräter, M. ; Wagner, K. ; Kurth, T. ; Richter, I. ; Binner, M. ; Hahn, D. ; Freudenberg, U. ; Werner, C. ; Guck, J. 3D microenvironment stiffness regulates tumor spheroid growth and mechanics via p21 and ROCK more Advanced Biosystems 3 (2019) 1900128
  • Freudenberg, U. ; Atallah, P. ; Limasale, Y. D. P. ; Werner, C. Charge-tuning of glycosaminoglycan-based hydrogels to program cytokine sequestration more Faraday Discussions 219 (2019) 244-251
  • Celikkaya, H. ; Cosacak, M. I. ; Papadimitriou, C. ; Popova, H. ; Bhattarai, P. ; Biswas, S. ; Siddiqui, T. ; Wistorf, S. ; Nevado-Alcalde, I. ; Naumann, L. ; Mashkaryan, V. ; Brandt, K. ; Freudenberg, U. ; Werner, C. ; Kizil, C. GATA3 promotes the neural progenitor state but not neurogenesis in 3D traumatic injury model of primary human cortical astrocytes more Frontiers in Cellular Neuroscience 13 (2019) Article Number: 23
  • Kunisch, E. ; Knauf, A.-K. ; Hesse, E. ; Freudenberg, U. ; Werner, C. ; Bothe, F. ; Diederichs, S. ; Richter, W. StarPEG/heparin-hydrogel based in vivo engineering of stable bizonal cartilage with a calcified bottom layer more Biofabrication 11 (2018) ID015001
  • Atallah, P. ; Schirmer, L. ; Tsurkan, M. ; Limasale, Y. D. P. ; Zimmermann, R. ; Werner, C. ; Freudenberg, U. In situ-forming, cell-instructive hydrogels based on glycosaminoglycans with varied sulfation patterns more Biomaterials 181 (2018) 227-239
  • Papadimitriou, C. ; Celikkaya, H. ; Cosacak, M. I. ; Mashkaryan, V. ; Bray, L. ; Bhattarai, P. ; Brandt, K. ; Hollak, H. ; Chen, X. ; He, S. ; Antos, C. L. ; Lin, W. ; Thomas, A. K. ; Dahlina, A. B. ; Kurth, T. ; Friedrichs, J. ; Zhang, Y. ; Freudenberg, 3D culture method for alzheimers disease modeling reveals interleukin-4 rescues A beta 42-induced Loss of human neural stem cell plasticity more Developmental Cell 46 (2018) 85-101
  • Vogler, S. ; Prokoph, S. ; Freudenberg, U. ; Binner, M. ; Tsurkan, M. ; Werner, C. ; Kempermann, G. Defined geldrop cultures maintain neural precursor cells more Scientific Reports 8 (2018) ID8433
  • Lohmann, N. ; Schirmer, L. ; Atallah, P. ; Wandel, E. ; Ferrer, R. A. ; Werner, C. ; Simon, J. C. ; Franz, S. ; Freudenberg, U. Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice more Experimental Dermatology 27 (2018) E18-E19, P0043