The new paper Sulfonated cryogel scaffolds for focal delivery in ex-vivo brain tissue cultures

by Dimitri Eigel, Romy Schuster, Max J. Männel, Julian Thiele, Martyna J. Panasiuk, Laura C. Andreae, Carmine Varicchio, Andrea Brancale, Petra B. Welzel, Wieland B. Huttner, Carsten Werner, Ben Newland and Katherine R. Long presents a novel user-friendly and robust cryogel-based tool for site-specific and reproducible manipulation of human brain tissue in culture. The completely synthetic, line-shaped, sulfonated microscale cryogels can reversibly bind and focally deliver dyes and reagents to ex-vivo primary tissue without tissue damage. This innovate approach has a great potential to enable the visualization and tracking of individual cells and can be further developed to focally apply pharmacologically active or genetically modifying substances to defined regions of tissue explants or slice cultures. The paper was published in Biomaterials.

12.04.2021

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