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Dr. Dietmar Appelhans

Head of department

Dr. Dietmar Appelhans
+49 (0)351 4658 353 +49 (0)351 4658 565

Secretary

Carmen Krause
+49 (0)351 4658 590 +49 (0)351 4658 565

Co-worker at the Institute of Macromolecular Chemistry, guided by Prof. Brigitte Voit

Fields of Research

General research interests are:

  • Synthesis, modification, characterisation and application of dendritic and dendronized polymers, especially sugar-decorated polymeric structures;
  • Using dendritic glycoarchitectures as anti-amyloidogenic agent toward beta-containing peptides and proteins in-vitro and to test its potential as neuro-protective materials in-vivo;
  • Establishment of peptide-ligand-neutravidin bioconjugates for the controlled targeting of drugs and drug complexes;
  • Polymersomes as enzymatic nanoreactors und carrier systems for enzymes as well as its use as biomimetic organelles;
  • Integration of polymersomes in multicompartment systems to fabricate biomimetic cell structures;
  • Objectives, such as diffusion properties, communication, loading and releasing of cargo (macro)molecules, but also adaptive and cyclic functions, concern the applicability of biomimetic structures and enzyme-transported/-loaded polymersomes;
  • Establishment of multienzymatic cascade reactions in microfluidic (multi)compartment systems and the application of hydrogels as valve material.

More details for dendritic polymers with oligosaccharide architectures (PDF, 104 KB)

Molecular modelling of a 2nd generation poly(propylene imine) dendrimer with 16 maltose substituents (picture from Dr. P. Friedel)