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Title Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke
Date 01.07.2019
Number 56407
Abstract Patients suffering from ischemic strokes have limited therapeutic options and are often left with considerable disabilities. To promote neurological recovery, angiogenesis has been proposed as a promising therapeutic target. So far, experimental efforts to enhance vessel growth have almost exclusively focused on vascular growth factor supplementation; this approach has been shown not to be clinically viable due to hemorrhagic risks. Here, we pursued an alternative approach by targeting the guidance molecule Nogo-A, which has been recently shown to inhibit developmental central nervous system angiogenesis. Blockage of the Nogo-A pathway results in restoration of a mature vascular bed within the periinfarct zone. Moreover, we observe enhanced recovery-associated tissue responses and regain of motor functions that strongly correlate with vascular growth.
URL https://doi.org/10.1073/PNAS.1905309116
Publisher Proceedings of the National Academy of Sciences of the United States of America : PNAS
Identifier
Citation Proceedings of the National Academy of Sciences of the United States of America : PNAS (2019) Jun 2019
DOI https://doi.org/10.1073/PNAS.1905309116
Authors Rust, R. ; Grönnert, L. ; Gantner, C. ; Enzler, A. ; Mulders, G. ; Weber, R. ; Siewert, A. ; Limasale, Y. D. P. ; Meinhardt, A. ; Maurer, M. ; Satori, A. ; Hofer, A.-S. ; Werner, C. ; Schwab, M.
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