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Title Glyco-pseudodendrimers on a polyester basis: Synthesis and investigation of protein-pseudodendrimer interaction
Date 08.07.2018
Number 55553
Abstract Molar mass and end group number of a hyperbranched polyester are significantly increased by its transformation to a pseudodendrimer. Three generations of pseudodendrimers are obtained from hyperbranched aliphatic polyester core by modification with a protected AB*2 monomer. A sequence of protection and deprotection steps leads to OH–terminated pseudodendrimers. NMR studies confirm maximum degree of branching in the first generation, which slightly decreases in the next two generations. Uniform, dense molecular structure formation was confirmed by MD simulation. Further modification to glyco–pseudodendrimers was performed with a–D–mannose leading to high molar masses and dense distribution of sugar units. The interaction of these sugar units with a plant lectin concanavalin A (Con A) was investigated using dynamic light scattering and cryogenic transmission electron microscopy. The protein–interaction studies of the glyco–pseudodendrimers confirm a loose network with Con A. The interaction activity depends on the generation number and modification degree.
Publisher Macromolecular Rapid Communications
Identifier
Citation Macromolecular Rapid Communications 39 (2018) ID1800364
DOI https://doi.org/10.1002/marc.201800364
Authors Firdaus, S. ; Geisler, M. ; Friedel, P. ; Banerjee, S. ; Appelhans, D. ; Voit, B. ; Lederer, A.
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