Title Poly(ethylene oxide)-b-poly(3-sulfopropyl methycrylate) block copolymers for calcium phosphate mineralization and biofilm inhibition
Date 28.11.2014
Number 44893
Abstract Poly(ethylene oxide) (PEO) has long been used as an additive in toothpaste, partly because it reduces biofilm formation on teeth. It does not, however, reduce the formation of dental calculus or support the remineralization of dental enamel or dentine. The present article describes the synthesis of new block copolymers on the basis of PEO and poly(3-sulfopropyl methacrylate) blocks using atom transfer radical polymerization. The polymers have very large molecular weights (over 106 g/mol) and are highly water-soluble. They delay the precipitation of calcium phosphate from aqueous solution but, upon precipitation, lead to relatively monodisperse hydroxyapatite (HAP) spheres. Moreover, the polymers inhibit the bacterial colonization of human enamel by Streptococcus gordonii, a pioneer bacterium in oral biofilm formation, in vitro. The formation of well-defined HAP spheres suggests that a polymer-induced liquid precursor phase could be involved in the precipitation process. Moreover, the inhibition of bacterial adhesion suggests that the polymers could be utilized in caries prevention.
Publisher Biomacromolecules
Citation Biomacromolecules 15 (2014) 3901-3914
Authors Mai, T. ; Rakhmatullina, E. ; Bleek, K. ; Boye, S. ; Yuan, J. ; Vökel, A. ; Gräwert, M. ; Cheaib, Z. ; Eick, S. ; Günter, C. ; Lederer, A. ; Lussi, A. ; Taubert, A.
Tags surface protein-peptides sodium lauryl sulfate dental biofilm streptococcus-gordonii in-vitro hydroxyapatite formation pellicle formation salivary pellicle tooth wear adsorption

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