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Title Extracellular matrix functionalized microcavities to control hematopoietic stem progenitor cell fate
Date 30.06.2011
Number 25943
Abstract Polymeric microcavities functionalized with extracellular matrix components were used as an experimental in vitro model to investigate principles of hematopoietic stem and progenitor cell (HSPC) fate control. Using human CD133+ HSPC we could demonstrate distinct differences in HSPC cycling and differentiation dependence on the adhesion ligand specificity (i.e., heparin, collagen I) and cytokine levels. The presented microcavity platform provides a powerful in vitro approach to explore the role of exogenous cues in HSPC fate decisions and can therefore be instrumental to progress in stem cell biology and translational research toward new therapies.
Publisher Macromolecular Bioscience
Identifier
Citation Macromolecular Bioscience 11 (2011) 739-747
DOI https://doi.org/10.1002/mabi.201000432
Authors Kurth, I. ; Franke, K. ; Pompe, T. ; Bornhäuser, M. ; Werner, C.
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