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Title Modular starPEG-heparin gels with bifunctional peptide linkers
Date 27.09.2010
Number 23265
Abstract Cell responsive materials are instrumental to regenerative therapies. Here, we report about a novel biohybrid hydrogel that consists of heparin and peptide-conjugated star-shaped poly(ethylene glycol), crosslinked by peptide units that combine matrix metalloproteinase (MMP) sensitivity and cell adhesive modules. Taking advantage of the high affinity of vascular endothelial growth factor to heparin, we illustrate the applicability of our hydrogels as a novel system that is supportive of cellular remodeling and three-dimensional migration of human endothelial cells.
Publisher Macromolecular Rapid Communications
Identifier
Citation Macromolecular Rapid Communications 31 (2010) 1529-1533
DOI https://doi.org/10.1002/marc.201000155
Authors Tsurkan, M. ; Chwalek, K. ; Levental, K. ; Freudenberg, U. ; Werner, C.
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