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Authors
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Bertolin, M.; Barbaro, V.; Tsurkan, M.; Tsurkan, S.; Arndt, S.; Ponzin, D.; Ferrari, S.
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Title
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P16-A111 Factors affecting the density of corneal endothelial cell cultures obtained from donor corneas
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Date
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21.08.2023
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Number
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0
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Abstract
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Purpose The shortage of donor corneas represents a worldwide problem, and corneal endothelial cell (CEC) therapy might be a promising alternative approach. CEC can be implanted alone, which has shown limited efficacy, or with a scaffold that holds the cells together as a monolayer tissue, thus imitating Descemet membrane endothelial keratoplasty. We believe that endothelial cell density (ECD) >2000 cells/mm2, a cut-off value that eye banks use to provide quality tissues for transplantation to surgeons, should also be adopted as a parameter to define the quality of CECs as a new Advanced Therapy Medicinal Product for clinical applications in patients with endothelial dystrophies.
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Publisher
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Wikidata
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Citation
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BMJ Open Ophthalmology 8 (2023) A7
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DOI
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https://doi.org/10.1136/bmjophth-2023-EEBA.15
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