Authors Bains, A.K. ; Behrens Wu, L. ; Richter, M. ; Magno, V. ; Rother, S. ; Cross, M. ; Werner, C. ; Wobus, M. ; Platzbecker, U.
Title P724: The bone marrow mesenchymal cell-derived extracellular matrix is significantly altered in patients with melodysplastic syndromes
Date 01.06.2022
Number 61151
Abstract Myelodysplastic syndromes (MDS) are characterised by ineffective hematopoiesis and peripheral cytopenia in one or more hematopoietic lineages. MDS is driven by genetic and epigenetic lesions in the hematopoietic clone itself, but also by changes in the bone marrow microenvironment. Here, the mesenchymal stromal cells (MSCs) regulate hematopoietic cell behaviour through cell-cell contact, paracrine signalling and metabolic support. The MSC-derived Extracellular matrix (ECM) plays a key role in coordinating both physical and biochemical interactions but the involvement of ECM in MDS has yet to be determined.
Publisher HemaSphere
Citation HemaSphere 6 (2022) 619-620

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