Authors
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Schirmer, L. ; Hoornaert, C. ; Le Blon, D. ; Eigel, D. ; Neto, C. ; Gumbleton, M. ; Welzel, P. ; Rosser, A. ; Werner, C. ; Ponsaerts, P. ; Newland, B.
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Title
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Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain
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Date
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01.09.2020
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Number
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58857
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Abstract
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Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain.
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Publisher
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Biomaterials Science
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Wikidata
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Q99546670
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Citation
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Biomaterials Science 8 (2020) 4997-5004
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DOI
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https://doi.org/10.1039/D0BM01249A
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Tags
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