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Authors
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Machalowski, T. ; Wysokowski, M. ; Zoltowska-Aksamitowska, S. ; Tsurkan, M. ; et al.,
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Title
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Spider Chitin. The biomimetic potential and applications of Caribena versicolor tubular chitin
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Date
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15.12.2019
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Number
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57233
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Abstract
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Diverse fields of modern technology and biomedicine can benefit from the application of ready-to-use chitin-based scaffolds. In this work we show for the first time the applicability of tubular and porous chitin from Caribena versicolor spiders as a scaffold for the development of an effective CuO/Cu(OH)2 catalyst for the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AM), and as a scaffold for the tissue engineering of selected cells. The formation of CuO/Cu(OH)2 phases on and within the chitinous tubes leads to a hybrid material with excellent catalytic performance with respect to the reduction of p-nitrophenol. On the other hand, experimental results provide for the first time strong evidence for the biocompatibility of spider chitin with different cell types, a human progenitor cell line (hPheo1), as well as cardiomyocytes differentiated from induced pluripotent stem cells (iPSC-CMs) that were cultured on a tube-like scaffold.
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Publisher
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Carbohydrate Polymers
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Wikidata
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Citation
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Carbohydrate Polymers 226 (2019) 115301
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DOI
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https://doi.org/10.1016/J.CARBPOL.2019.115301
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Tags
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