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Authors
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Rust, R. ; Grönnert, L. ; Gantner, C. ; Enzler, A. ; Mulders, G. ; Weber, R. ; Siewert, A. ; Limasale, Y. D. P. ; Meinhardt, A. ; Maurer, M. ; Satori, A. ; Hofer, A.-S. ; Werner, C. ; Schwab, M.
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Title
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Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke
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Date
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09.07.2019
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Number
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56407
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Abstract
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Patients suffering from ischemic strokes have limited therapeutic options and are often left with considerable disabilities. To promote neurological recovery, angiogenesis has been proposed as a promising therapeutic target. So far, experimental efforts to enhance vessel growth have almost exclusively focused on vascular growth factor supplementation; this approach has been shown not to be clinically viable due to hemorrhagic risks. Here, we pursued an alternative approach by targeting the guidance molecule Nogo-A, which has been recently shown to inhibit developmental central nervous system angiogenesis. Blockage of the Nogo-A pathway results in restoration of a mature vascular bed within the periinfarct zone. Moreover, we observe enhanced recovery-associated tissue responses and regain of motor functions that strongly correlate with vascular growth.
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Publisher
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Proceedings of the National Academy of Sciences of the United States of America : PNAS
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Wikidata
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Q92998712
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Citation
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Proceedings of the National Academy of Sciences of the United States of America : PNAS 116 (2019) 14270-14279
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DOI
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https://doi.org/10.1073/PNAS.1905309116
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Tags
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