Authors Grombe, R. ; Gouzy, M.-F. ; Freudenberg, U. ; Pompe, T. ; Zschoche, St. ; Simon, F. ; Eichhorn, K.-J. ; Janke, A. ; Voit, B. ; Werner, C.
Title Sulfated cellulose thin films with antithrombin affinity
Date 29.10.2009
Number 20348
Abstract Cellulose thin films were chemically modified by in situ sulfation to produce surfaces with anticoagulant characteristics. Two celluloses differing in their degree of polymerization (DP): CEL I (DP 215–240) and CEL II (DP 1300–1400)<br />were tethered to maleic anhydride copolymer (MA) layers and subsequently exposed to SO3·NMe3 solutions at elevated temperature. The impact of the resulting sulfation on the physicochemical properties of the cellulose films was investigated with respect to film thickness, atomic composition, wettability and roughness. The sulfation was optimized to gain a maximal surface concentration of sulfate groups. The scavenging of antithrombin (AT) by the surfaces was determined to conclude on their potential anticoagulant properties.
Publisher eXPRESS Polymer Letters
Citation eXPRESS Polymer Letters 3 (2009) 733-742
Tags biocompatible polymers cellulose sulfation maleic anhydride copolymer maleic-anhydride copolymers hemodialysis membranes complement activation immobilized heparin biomaterials derivatives coatings ellipsometry spectroscopy layers

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