Authors Voit, B. ; Baier, A. ; Gramm, S. ; Nitschke, M. ; Rueda-Sanchez, J. C. ; Schmaljohann, D. ; Steinert, V. ; Werner, C. ; Zschoche, St.
Title Hydrophilic, amphiphilic and thermo-responsive gels synthesized for biomedical applications
Date 01.03.2006
Number 13345
Abstract Several hydrophilic, amphiphilic and thermoresponsive polymers are reported, which can be attached to polymeric substrates by using macroinitiators, 'grafting onto' processes or plasma and electron beam activation. Poly(acrylic acid) hydrogel layers grafted from a thin macroinitiator layer could be used to reduce the friction of polymeric catheters and to allow better sliding of the tubes into the blood vessels without damaging tissue. A similar approach could be used to fix hydrogel layers on balloon catheters, which are able to carry anticlotting drugs being released after the fixation of the catheter/stent within the blood vessel. A variety of amphiphilic graft copolymers and gels have been prepared based on oxazoline chemistry, which allows inducing heterogeneity into the gel structure leading to specific swelling properties. Copolymerization with N-isopropylacrylamide (NIPAAm) also incorporated thermoresponsive behaviour in the gels. Copolymers of NIPAAm with poly(ethylene glycol) macromonomers allowed the preparation of cell-compatible thermoresponsive materials immobilized on surfaces for cell release studies.
Publisher e-Polymers :
Citation e-Polymers : (2006) 8 pages

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