Publications
| Authors | Friedrichs, J.; Werner, C. |
|---|---|
| Title |
Cholesterol can make surfaces non-stick
Research briefing |
| Date | 21.06.2023 |
| Number | 0 |
| Abstract | <strong>The question </strong> Functional biological interfaces — surfaces on the outside of and within living organisms — depend on the fine-tuned control of their interactions with the multiple components of their environments1. Collembola (springtails) are a group of widespread, primarily wingless invertebrates. Their skin needs to remain pristine, even in soil, because they respire through the skin and blocking it would result in suffocation. We previously 2 identified cholesterol, a widespread molecule with balanced hydrophilic and hydrophobic properties, as a constituent of Collembola skin (Fig. 1a). In our study, we found that layers containing cholesterol effectively prevent the adhesion of other biological molecules and cells (bioadhesion). We investigated the mechanism underlying the repulsive effects of cholesterol and the structural requirements of both the molecule and the layer. Our findings could provide a blueprint for making engineered surfaces with minimal bioadhesion. |
| Publisher | Nature - Research Briefings |
| Wikidata | |
| Citation | Nature - Research Briefings |
| DOI | https://doi.org/10.1038/d41586-023- 01681-y |
| Tags |