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Authors
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Li, Y. ; Männel, M. J. ; Hauck, N. ; Patel, H. ; Auernhammer, G. ; Chae, S. ; Fery, A. ; Li, J. ; Thiele, J.
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Title
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Embedment of quantum dots and biomolecules in a dipeptide hydrogel formed in situ using microfluidics
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Date
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15.03.2021
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Number
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59953
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Abstract
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As low-molecular-weight hydrogelators, dipeptide hydrogel materials are suited for embedding multiple organic molecules and inorganic nanoparticles. Herein, a simple but precisely controllable method is presented that enables the fabrication of dipeptide-based hydrogels by supramolecular assembly inside microfluidic channels. Water-soluble quantum dots (QDs) as well as premixed porphyrins and a dipeptide in dimethyl sulfoxide (DMSO) were injected into a Y-shaped microfluidic junction. At the DMSO/water interface, the confined fabrication of a dipeptide-based hydrogel was initiated. Thereafter, the as-formed hydrogel flowed along a meandering microchannel in a continuous fashion, gradually completing gelation and QD entrapment. In contrast to hydrogelation in conventional test tubes, microfluidically controlled hydrogelation led to a tailored dipeptide hydrogel regarding material morphology and nanoparticle distribution.
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Publisher
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Angewandte Chemie - International Edition
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Wikidata
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Citation
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Angewandte Chemie - International Edition 60 (2021) 6724-6732
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DOI
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https://doi.org/10.1002/ANIE.202015340
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