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Authors Appelhans, D. ; Stastny, V. ; Komber, H. ; Voigt, D. ; Voit, B. ; Lhoták, P. ; Stibor, I.
Title Novel dentritic cores based on thiacalix[4]arene derivatives
Date 01.09.2004
Number 12519
Abstract Thiacalix[4]arenes possessing carboxylic groups were used for the design of potential dendritic cores with amino surface groups. The known tetraacetic acid in the 1,3-alternate conformation gave the desired product in very low yield because of steric hindrance on thiacalix[4]arene moiety. Therefore, synthetic strategy based on withdrawing of the carboxyl groups via benzylic spacer from the thiacalix[4]arene moiety was successfully applied for the realization of novel thiacalix[4]arenes bearing two or four protected lysine units.
Publisher Tetrahedron Letters
Wikidata
Citation Tetrahedron Letters 45 (2004) 7145-7149
DOI https://doi.org/10.1016/j.tetlet.2004.07.085
Tags thiacalixarenes benzylic spacer dendritic core amino surface group state structural-analysis binding-properties dendrimers thiacalixarene calixarene receptors acid

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