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Title Nanocarriers in photodynamic therapy-in vitro and in vivo studies
Date 25.11.2019
Number 57748
Abstract Photodynamic therapy (PDT) is a minimally invasive technique which has proven to be successful in the treatment of several types of tumors. This relatively simple method exploits three inseparable elements: phototoxic compound (photosensitizer [PS]), light source, and oxygen. Upon irradiation by light with specified wavelength, PS generates reactive oxygen species, which starts the cascade of reactions leading to cell death. The positive therapeutic outcome of PDT may be limited due to several aspects, including low water solubility of PSs, hampering their effective administration and blood circulation, as well as low tumor specificity, inefficient cellular uptake and activation energies requiring prolonged illumination times. One of the promising approaches to overcome these obstacles involves the use of carrier systems modulating pharmacokinetics and pharmacodynamics of the PSs. In the present review, we summarized current in vitro and in vivo studies regarding the use of nanoparticles as potential delivery devices for PSs to enhance their cellular uptake and cytotoxic properties, and thus—the therapeutic outcome of PDT.
URL https://doi.org/10.1002/WNAN.1599
Publisher Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Identifier
Citation Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology (2019) Early View
DOI https://doi.org/10.1002/WNAN.1599
Authors Sztandera, K. ; Gorzkiewicz, M. ; Klajnert-Maculewicz, B.
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