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Title Thermoresponsive catechol based-polyelectrolyte complex coatings for controlled release of bortezomib
Date 02.12.2019
Number 57456
Abstract To overcome the high relapse rate of multiple myeloma (MM), a drug delivery coating for functionalization of bone substitution materials (BSM) is reported based on adhesive, catechol-containing and stimuli-responsive polyelectrolyte complexes (PECs). This system is designed to deliver the MM drug bortezomib (BZM) directly to the anatomical site of action. To establish a gradual BZM release, the naturally occurring caffeic acid (CA) is coupled oxidatively to form poly(caffeic acid) (PCA), which is used as a polyanion for complexation. The catechol functionalities within the PCA are particularly suitable to form esters with the boronic acid group of the BZM, which are then cleaved in the body fluid to administer the drug. To achieve a more thorough control of the release, the thermoresponsive poly(N-isoproplyacrylamide-co-dimethylaminoethylmethacrylate) (P(NIPAM-co-DMAEMA)) was used as a polycation. Using turbidity measurements, it was proven that the lower critical solution temperature (LCST) character of this polymer was transferred to the PECs. Further special temperature dependent attenuated total reflection infrared spectroscopy (ATR-FTIR) showed that coatings formed by PEC immobilization exhibit a similar thermoresponsive performance. By loading the coatings with BZM and studying the release in a model system, via UV/Vis it was observed, that both aims, the retardation and the stimuli control of the release, were achieved.
URL https://doi.org/10.3390/IJMS20236081
Publisher International Journal of Molecular Sciences
Identifier
Citation International Journal of Molecular Sciences 20 (2019) 6081
DOI https://doi.org/10.3390/IJMS20236081
Authors Reis, B. ; Vehlow, D. ; Rust, T. ; Kuckling, D. ; Müller, M.
Tags catechol chemistry poly(caffeic acid) polyelectrolyte complex coatings thermoresponsive coatings controlled release bortezomib multiple myeloma

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