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Title Glycogen as a building block for advanced biological materials
Date 29.10.2019
Number 57343
Abstract Biological nanoparticles found in living systems possess distinct molecular architectures and diverse functions. Glycogen is a unique biological polysaccharide nanoparticle fabricated by nature through a bottom–up approach. The biocatalytic synthesis of glycogen has evolved over time to form a nanometer–sized dendrimer–like structure (20–150 nm) with a highly branched surface and a dense core. This makes glycogen markedly different from other natural linear or branched polysaccharides and particularly attractive as a platform for biomedical applications. Glycogen is inherently biodegradable, nontoxic, and can be functionalized with diverse surface and internal motifs for enhanced biofunctional properties. Recently, there has been growing interest in glycogen as a natural alternative to synthetic polymers and nanoparticles in a range of applications. Herein, the recent literature on glycogen in the material–based sciences, including its use as a constituent in biodegradable hydrogels and fibers, drug delivery vectors, tumor targeting and penetrating nanoparticles, immunomodulators, vaccine adjuvants, and contrast agents, is reviewed. The various methods of chemical functionalization and physical assembly of glycogen nanoparticles into multicomponent nanodevices, which advance glycogen toward a functional therapeutic nanoparticle from nature and back again, are discussed in detail.
URL https://doi.org/10.1002/ADMA.201904625
Publisher Advanced Materials
Identifier
Citation Advanced Materials (2019) Early view
DOI https://doi.org/10.1002/ADMA.201904625
Authors Besford, Q.A. ; Cavalieri, F. ; Caruso, F.
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