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Title Unusual enhancement of doxorubicin activity on co-delivery with polyhedral oligomeric silsesquioxane (POSS)
Date 27.07.2017
Number 53551
Abstract Polyhedral oligomeric silsesquioxane (POSS), bearing eight 3-chloroammoniumpropyl substituents, was studied as a potential nanocarrier in co-delivery systems with doxorubicin (DOX). The toxicity of doxorubicin and POSS:DOX complexes at four different molar ratios (1:1; 1:2, 1:4, 1:8) towards microvascular endothelial cells (HMEC-1), breast cancer cells (MCF-7), and human cervical cancer endothelial cells (HeLa) was determined. The rate of penetration of the components into the cells, their cellular localization and the hydrodynamic diameter of the complexes was also determined. A cytotoxicity profile of POSS:DOX complexes indicated that the POSS:DOX system at the molar ratio of 1:8 was more effective than free DOX. Confocal images showed that DOX co-delivery with POSS allowed for more effective penetration of doxorubicin through the cell membrane. Taking all the results into account, it can be claimed that the polyhedral oligomeric silsesquioxane (T8-POSS) is a promising, complex nanocarrier for doxorubicin delivery.
URL http://dx.doi.org/10.3390/ma10050559
Publisher Materials (Open Access)
Identifier 0
Citation Materials (Open Access) 10 (2017) ID559
DOI http://dx.doi.org/10.3390/ma10050559
Authors Sobierajska, E. ; Konopka, M. ; Janaszewska, A. ; Piorecka, K. ; Blauz, A. ; Klajnert-Maculewicz, B. ; Stanczyk, M. ; Stanczyk, W. A.
Tags poss silsesquioxane doxorubicin co-delivery in vitro toxicity

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