Title Dynamic docking and undocking processes adressing selectively the outside and inside of polymersome
Date 17.09.2017
Number 53525
Abstract Increasing complexity and diversity of polymersomes and their compartments is a key issue for mimicking cellular functions and protocells. Thus, new challenges arise in terms of achieving tunable membrane permeability and combining it with control over the membrane diffusion process, and thus enabling a localized and dynamic control of functionality and docking possibilities within or on the surface of polymeric compartments. This study reports the concept of polymersomes with pH-tunable membrane permeability for controlling sequential docking and undocking processes of small molecules and nanometer-sized protein mimics selectively on the inside and outside of the polymersome membrane as a further step toward the design of intelligent multifunctional compartments for use in synthetic biology and as protocells. Host–guest interactions between adamantane and ß-cyclodextrin as well as noncovalent interactions between poly(ethylene glycol) tails and ß-cyclodextrin are used to achieve selective and dynamic functionalization of the inner and outer spheres of the polymersome membrane.
Publisher Macromolecular Rapid Communications
Identifier 0
Citation Macromolecular Rapid Communications 38 (2017) ID1700486
Authors Iyisan, B. ; Siedel, A. C. ; Gumz, H. ; Yassin, M. ; Kluge, J. ; Gaitzsch, J. ; Formanek, P. ; Moreno, S. ; Voit, B. ; Appelhans, D.

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