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Title Real-time characterization if fibrionogen interaction with modified titanium dioxide film by quartz crystal microbalance with dissipation
Date 06.11.2014
Number 44722
Abstract The adsorption of fibrinogen can be used as a quick indicator of surface haemocompatibility because of its prominent role in coagulation and platelet adhesion. In this work the molecular interaction between fibrinogen and a modified titanium oxide surface/platelet has been studied by quartz crystal microbalance with dissipation (QCM-D) in situ. In order to further characterize the conformation of adsorbed fibrinogen, aC and ·-chain antibody were used to check the orientation and denaturation of fibrinogen on solid surface. QCM-D investigations revealed the fibrinogen have the trend to adsorb on hydrophilic surface in a side-on orientation by positively charged aC domains, which would reduce the exposure of platelet bonding site on · chain and enable less platelet adhesion and be activated. These observations suggest that certain conformations of adsorbed fibrinogen are less platelet adhesive than others, which opens a possibility for creating a non-platelet adhesive substrates. © 2014 Chinese Physical Society
Publisher Chinese Journal of Chemical Physics
Identifier
Citation Chinese Journal of Chemical Physics 27 (2014) 355-360
DOI https://doi.org/03/355-360
Authors Zhao, A. S. ; Wang, Z. ; Zhu, X. H. ; Maitz, M.F. ; Huang, N.
Tags adhesion quartz titanium adsorption metallic thin films

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