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Title Direct correlation of electrochemical behaviors with anti-thrombogenicity of semiconducting titanium oxide films
Date 10.01.2014
Number 41423
Abstract Biomaterials-associated thrombosis is dependent critically upon electrochemical response of fibrinogen on material surface. The relationship between the response and anti-thrombogenicity of biomaterials is not well-established. Titanium oxide appears to have good anti-thrombogenicity and little is known about its underlying essential chemistry. We correlate their anti-thrombogenicity directly to electrochemical behaviors in fibrinogen containing buffer solution. High degree of inherent n-type doping was noted to contribute the impedance preventing charge transfer from fibrinogen into film (namely its activation) and consequently reduced degree of anti-thrombogenicity. The impedance was the result of high donor carrier density as well as negative flat band potential.
Publisher Journal of Biomaterials Applications
Identifier
Citation Journal of Biomaterials Applications 28 (2014) 719-728
DOI https://doi.org/10.1177/0885328213476911
Authors Wan, G. ; Lv, Bo ; Jin, G. ; Maitz, M.F. ; Zhou, J. ; Huang, N.
Tags anti-thrombogenicity biomaterials-associated thrombosis blood compatibility interfacial charge transfer electrochemical behavior titanium oxide film

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