Authors
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Wang, X. ; Moreno, S. ; Boye, S. ; Wen, P. ; Zhang, K. ; Formanek, P. ; Lederer, A. ; Voit, B. ; Appelhans, D.
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Title
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Feedback-induced and oscillating pH regulation of a binary enzyme-polymersomes system
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Date
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20.08.2021
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Number
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59263
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Abstract
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The stimuli-triggered regulating ability is a basic characteristic of biological systems, and it is always cyclic in nature. To mimic this stimuli-triggered regulation process for the construction of artificial cellular structures and functions is a challenge. Here, we present the development of artificial organelles system (AOS) with stimuli-trigged regulation ability consisting of the coexisting glucose oxidase-(GOx)-loaded pH-responsive polymersomes A (GOx-Psomes A) and urease-loaded pH-responsive polymersomes B (Urease-Psomes B) with orthogonal-responsive membranes. The addition of chemical fuels triggers the out-of-equilibrium state of AOS at which the pH decreases (glucose as fuel) or increases (urea as fuel). The pH change results in the catalytic “on” or “off” switch of GOx-Psomes A and Urease-Psomes B at different states due to their different pH responsiveness. Thus, this AOS with feedback-induced and oscillating pH-regulating ability paves the way for the construction of artificial eukaryotic cell biomimetics with controlled communications and metabolism mimicking.
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Publisher
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Chemistry of Materials
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Wikidata
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Q110208763
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Citation
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Chemistry of Materials 33 (2021) 6692-6700
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DOI
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https://doi.org/10.1021/ACS.CHEMMATER.1C00897
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Tags
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