Authors Murata, H. ; Baker, S.L. ; Kaupbayeva, B. ; Lewis, D.J. ; Zhang, L. ; Boye, S. ; Lederer, A. ; Russell, T.P.
Title Ligands and characterization for effective bio-atom-transfer radical polymerization
Date 01.01.2020
Number 57204
Abstract Three new morpholine–based ligands were synthesized to better control ATRP in aqueous media. 4–(bis(N,N–diethylaminoethyl)aminoethyl)morpholine (MMA), N,N–diethylaminoethyl–bis(2–morpholinoethyl)amine, and tris(2–morpholinoethyl)amine ligands were created and investigated to better understand the effect of electron withdrawing groups on the degree of control obtained under aqueous ATRP conditions. Polymerization performance of these ligands with the neutral oligo(ethylene glycol) methyl ether methacrylate and zwitterionic carboxybetaine methacrylate monomers was compared with tris(2–(diethylamino)ethyl)amine (Et6TREN) ligand. The new ligands showed decreased polymerization rates and yielded polymers with lower dispersities than those synthesized with Et6TREN. These results indicated that altering the basicity of the central tertiary amine is an important factor in controlling the stability of the copper(I) complex, leading to better control over aqueous ATRP. Finally, uniform protein–polymer conjugates were synthesized with the MMA ligand using protein–ATRP. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019
Publisher Journal of Polymer Science: Part A: Polymer Chemistry
Wikidata Q105192773
Citation Journal of Polymer Science: Part A: Polymer Chemistry 58 (2020) 42-47

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