Authors Wronska, N. ; Majoral, J. P. ; Appelhans, D. ; Bryszewska, M. ; Lisowska, K.
Title Synergistic effects of anionic/cationic dendrimers and levofloxacin on antibacterial activities
Date 23.08.2019
Number 57040
Abstract Despite the numerous studies on dendrimers for biomedical applications, the antibacterial activity of anionic phosphorus dendrimers has not been explored. In our research, we evaluated the antibacterial activity of modified polycationic and polyanionic dendrimers in combination with levofloxacin (LVFX) against Gram-negative (Escherichia coli ATCC 25922, Proteus hauseri ATCC 15442) and Gram-positive (Staphylococcus aureus ATCC 6538) bacteria. In the case of Gram-negative bacteria, we concluded that a combination of dendrimers and antibiotic gave satisfactory results due to a synergistic effect. The use of fluoroquinolone antibiotics, such as LVFX, not only caused resistance in disease-causing microorganisms but also increased environmental pollution. Therefore, reduction of drug dosage is of general interest.
Publisher Molecules
Citation Molecules 24 (2019) 2894
Tags dendrimers antibacterial activity levofloxacin synergistic effects

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