Authors Bittrich, E. ; Stamm, M. ; Uhlmann, P.
Title Functional biointerfaces tailored by "Gafting-To" brushes, Chapter 10 in: Polymer and Biopolymer Brushes, ed. Azzaroni, O; Szleifer, I.
Polymer and Biopolymer Brushes: for Materials Science and Biotechnology, Azzaroni, O; Szleifer, I., ed.
Date 01.12.2017
Number 53993
Abstract A review of the development of polymer brush coatings toward biointerfaces with emphasis on "grafting-to" brushes is presented. Stimuli-responsivity, grafting of mixed and gradient brushes, as well as postfunctionalization with click chemistry are shown to lead to functional surface coatings that can be tailored to create selective interaction behavior. Hybrid brush-nanostructures like nanoparticles immobilized in brushes or brushes grafted to sculptured thin films are discussed as model interfaces to study biomolecule interaction with artificial surfaces but also have potential in sensing devices. Nonfouling and low-fouling polymer brush layers as well as polyelectrolyte brush--mediated protein adsorption are reviewed, and the suitability of these brush surfaces for cell adhesion and interaction is shown. Poly(N-isopropyl acrylamide) (PNIPAAm) "grafting-to" brushes are discussed for the harvesting of viable three-dimensional cell cultures, and growth factor immobilization on polyelectrolyte brushes as an example for the generation of a bioactive brush surface. <br /><br />Polymer and Biopolymer Brushes : Fundamentals and Applications in Materials Science and Biotechnology<br />ISBN 978-1-119-45501-1
Publisher Wiley & Sons, Inc.
Citation Wiley & Sons, Inc. (2017) 287-331
Tags cell adhesion click chemistry grafting to nanoparticles nanostructures protein resistant stimuli responsive

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