Authors Horsch, J. ; Wilke, P. ; Pretzler, M. ; Seuss, M. ; Melnyk, I. ; Remmler, D. ; Fery, A. ; Rompel, A. ; Börner, H. G.
Title Polymerizing like the mussels do: From artificial mussel foot proteins toward resistant glues
Date 24.09.2018
Number 53793
Abstract A novel strategy to generate adhesive protein analogues by enzyme–induced polymerization of peptides is reported. Polymerization of unimers relies on tyrosinase oxidation of tyrosine to Dopaquinone, which rapidly forms cysteinyldopa with free thiols from cysteine, thereby linking unimers and generating adhesive polymers. The resulting artificial protein analogues show strong adsorption to different surfaces, even resisting hypersaline conditions. Remarkable adhesion energies up to 16.2 mJ/m² are found in single adhesion events and average values are superior to those measured for mussel foot proteins that constitute the gluing interfaces.
Publisher Nature Chemistry
Citation Nature Chemistry 57 (2018) Accepted Article

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