Authors
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Franiak-Pietryga, I. ; Maciejewski, H. ; Ziemba, B. ; Appelhans, D. ; Voit, B. ; Misiewicz, M. ; Robak, T. ; Trelinski, J. ; Bryszewska, M. ; Borowiec, M.
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Title
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Blockage of Wnt/B-catenin signaling by nanoparticles reduces survival and proliferation of CLL cells in vitro
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Date
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31.12.2015
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Number
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53425
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Abstract
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The Wnt pathway is critical for the proliferation and cell fate determination of many cell types, including B cells of chronic lymphocytic leukemia (CLL). Wnt proteins act on target cells by binding to the Frizzled (Fz)/low-density lipoprotein (LRP) complex at the cell membrane. In the hematopoietic system, Wnt/ß-catenin signaling pathway has been shown to be important in the control of the survival, proliferation and differentiation of hematopoietic cells.<br />Nanotechnology, a new and promising field, may be of use in medicine and the pharmaceutical industry. Dendrimers are nanoparticles of dendritic architecture. We have already proved the influence of PPI-G4-OS-M3 dendrimers in cultures in vitro on CLL cells apoptosis. CLL lymphocytes are characterized by the failure in the apoptosis pathway, but it is also proved that they manifest increased proliferation.<br />Herein, the objective was to evaluate how MEC-1 cells survival and proliferation in vitro is affected by blockage of Wnt pathway by PPI-G4-OS-M3 dendrimer comparing to FA.
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Publisher
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Blood
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Wikidata
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Citation
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Blood 126 (2015) ID3699
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DOI
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http://www.bloodjournal.org/content/126/23/3699
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Tags
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