Authors Mai, T. ; Boye, S. ; Yuan, J. ; Völkel, A. ; Gräwert, M. ; Günter, C. ; Lederer, A. ; Taubert, A.
Title Poly(ethylene oxide)-based block copolymers with very high molecular weights for biomimetic calcium phosphate mineralization
Date 13.11.2015
Number 48401
Abstract The article is the first report on the effects of poly(ampholyte)s and poly(betaine)s on the biomimetic formation of calcium phosphate. We have synthesized a series of di- and triblock copolymers based on a non-ionic poly(ethylene oxide) block and several charged methacrylate monomers, 2-(Trimethylamino)ethyl methacrylate, 2-((3-Cyanopropyl)-dimethylammonium)ethyl methacrylate chloride, 3-Sulfopropyl methacrylate potassium salt, and [2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide. The resulting copolymers are either positively charged, ampholytic, or betaine block copolymers. All polymers have very high molecular weights of over 106 g/mol. All polymers are water-soluble and show a strong effect on the formation and dissolution of calcium phosphate. The strongest effects are observed with triblock copolymers based on a large poly(ethylene oxide) middle block (nominal Mn = 100’000 g/mol). Surprisingly, the data show that there is a need for positive charges in the polymers, but that the exact position of the charge in the polymer is of minor importance for both calcium phosphate precipitation and dissolution.
Publisher RSC Advances
Citation RSC Advances 5 (2015) 103494-103505

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