Authors Baghaei, B. ; Jafari, S.H. ; Khonakdar, H. A. ; Saeb, M. R. ; Wagenknecht, U. ; Heinrich, G.
Title A multioptimization approach to assesment of drug delivery of PLGA nanoparticles: Simultaneous control of particle size and release behavior
Date 24.07.2015
Number 46863
Abstract A multiple optimization strategy was implemented on the experimental data obtained in this study to assess drug-delivery behavior of poly(D,L-lactide-co-glycolide) (PLGA) particles. Albumin–fluorescein isothiocyanate conjugate (FITC-albumin)-loaded PLGA micro- and nanoparticles were prepared by water-in-oil-in-water double emulsion method. The experiments were carried out based on L8 Taguchi design where the effects of PLGA molecular weight, PLGA concentration in the oil phase, and sonication rate in the second emulsification step of preparation process on particle size and percentage of initial burst release of PLGA were discussed. Multioptimization toward PLGA particle size and initial burst elucidated that all aforementioned variables affect the characteristics of PLGA particles, but PLGA molecular weight was appeared as the most significant factor among studied variables. Multifarious optimizations were tested and executed varying the aforementioned factors to minimize both the size and percentage of initial burst of PLGA particles. The FTIR experiment of the optimal formulation showed the successful incorporation of the drug into the particles. These results enable careful selection and definition of optimal process parameters for the preparation of PLGA nanoparticles with sustained release properties. Furthermore, the methodology developed in this work introduces a useful tool to meet a drug delivery system with optimal release behavior.
Publisher International Journal of Polymeric Materials and Polymeric Biomaterials
Citation International Journal of Polymeric Materials and Polymeric Biomaterials 64 (2015) 641-652

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