Authors
|
Striegler, C. ; Schumacher, M. ; Effenberg, C. ; Müller, M. ; Seckinger, A. ; Hose, D. ; Voit, B. ; Gelinsky, M. ; Appelhans, D.
|
Title
|
Dendritic glycopolymer as drug delivery system for proteasome inhibitor bortezomib in a calcium phosphate bone cement: First steps toward a local therapy of osteolytic bone lesions
|
Date
|
28.05.2015
|
Number
|
42522
|
Abstract
|
Establishment of drug delivery system (DDS) in bone substitute materials for local treatment of bone defects still requires ambitious solutions for a retarded drug release. We present two novel DDS, a weakly cationic dendritic glycopolymer and a cationic polyelectrolyte complex, composed of dendritic glycopolymer and cellulose sulfate, for the proteasome inhibitor bortezomib. Both DDS are able to induce short-term retarded release of bortezomib from calcium phosphate bone cement in comparison to a burst-release of the drug from bone cement alone. Different release parameters have been evaluated to get a first insight into the release mechanism from bone cements. In addition, biocompatibility of the calcium phosphate cement, modified with the new DDS was investigated using human mesenchymal stromal cells.
|
Publisher
|
Macromolecular Bioscience
|
Wikidata
|
Q53675025
|
Citation
|
Macromolecular Bioscience 15 (2015) 1283-1295
|
DOI
|
https://doi.org/10.1002/mabi.201500085
|
Tags
|
calcium phosphate bone cement dendritic glycopolymer drug release polyelectrolyte complex poly(propylene imine) dendrimers diagnosed multiple-myeloma differentiation in-vitro hyperbranched polymers branching motifs om-peis nanoparticles glycodendrimers ar
|