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Authors
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Appelhans, D. ; Stastny, V. ; Komber, H. ; Voigt, D. ; Voit, B. ; Lhoták, P. ; Stibor, I.
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Title
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Novel dentritic cores based on thiacalix[4]arene derivatives
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Date
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01.09.2004
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Abstract
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Thiacalix[4]arenes possessing carboxylic groups were used for the design of potential dendritic cores with amino surface groups. The known tetraacetic acid in the 1,3-alternate conformation gave the desired product in very low yield because of steric hindrance on thiacalix[4]arene moiety. Therefore, synthetic strategy based on withdrawing of the carboxyl groups via benzylic spacer from the thiacalix[4]arene moiety was successfully applied for the realization of novel thiacalix[4]arenes bearing two or four protected lysine units.
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Journal
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Tetrahedron Letters 45 (2004) 7145-7149
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DOI
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https://doi.org/10.1016/j.tetlet.2004.07.085
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