Dr. Claudia Sperling

Dr. Claudia Sperling

Dr. Claudia Sperling
Biofunctional Polymer Materials
Tel. +49 (0)351 4658 274 / Fax +49 (0)351 4658 533
Quicklinks Hemocompatible Interfaces

Field of Work

Claudia Sperling is responsible for the research on hemocompatible interfaces as a part of the research topic Biofunctional Polymermaterials at the IPF/Max Bergmann Center of Biomaterials Dresden.


  1. Fischer, M.; Baptista, C. P.; Concalves, I. C.; Ratner, B. D.; Sperling, C.; Werner, C.; Martins, C. L.; Barbosa, M. A.
    The effect of octadecyl chain immobilization on the hemocompatibility of poly (2-hydroxyethyl methycrylate) more
    Biomaterials 33 (2012) 7677-7685

  2. Maitz, M.F.; Sperling, C.; Werner, C.
    Immobilization of the irreversible thrombin inhibitor D-Phe-Pro-Arg-chloromethylketone: A concept for hemocompatible surfaces? more
    Journal of Biomedical Materials Research Part A 94 (2010) 905-912

  3. Fischer, M.; Sperling, C.; Tengvall, P.; Werner, C.
    The ability of surface characteristics of materials to trigger leukocyte tissue factor expression more
    Biomaterials 31 (2010) 2498-2507

  4. Fischer, M.; Sperling, C.; Werner, C.
    Synergistic effect of hydrophobic and anionic surface groups triggers blood coagulation in vitro more
    Journal of Materials Science : Materials in Medicine 21 (2009) 931-937

  5. Sperling, C.; Fischer, M.; Maitz, M.F.; Werner, C.
    Blood coagulation on biomaterials requires combination of distinct activation processes more
    Biomaterials 30 (2009) 4447-4456

  6. Maitz, M.F.; Teichmann, J.; Sperling, C.; Werner, C.
    Surface endotoxin contamination and hemocompatibiliy evaluation of materials more
    Journal of Biomedical Materials Research Part B: Applied Biomaterials 90B (2009) 18-25

  7. Werner, C.; Maitz, M.F.; Sperling, C.
    Current strategies towards hemocompatible coatings more
    Journal of Materials Chemistry 17 (2007) 3376-3384

  8. Sperling, C.; Maitz, M.F.; Talkenberger, S.; Gouzy, M.-F.; Groth, T.; Werner, C.
    In vitro blood reactivity to hydroxylated and non-hydroxylated polymer surfaces more
    Biomaterials 28 (2007) 3617-3625

  9. Grombe, R.; Gouzy, M.-F.; Maitz, M.F.; Freudenberg, U.; Zschoche, St.; Simon, F.; Pompe, T.; Sperling, C.; Werner, C.
    Sulfated glycopolymer thin films - preparation, characterization, and biological activity more
    Macromolecular Bioscience 7 (2007) 195-200

  10. Gouzy, M.-F.; Sperling, C.; Salchert, K.; Pompe, T.; Rauwolf, C.; Werner, C.
    Benzamidine-based coatings: Implication of inhibitor structure on the inhibition of coagulation enzymes in solution and in vitro hemocompatibility assessment more
    Biointerphases 1 (2006) S.146-155

  11. Sperling, C.; Houska, M.; Brynda, E.; Streller, U.; Werner, C.
    In vitro hemocompatibility of albumin-heparin multilayer coatings on polyethersulfone prepared by the layer-by-layer technique more
    Journal of Biomedical Materials Research Part A 76 (2006) 681-689

  12. Sperling, C.; Gouzy, M.-F.; Salchert, K.; Streller, U.; Rauwolf, C.; Werner, C.
    Bestimmung der Blutverträglichkeit von Materialoberflächen mit immobilisiertem Thrombininhibitor more
    Biomaterialien 6 (2005) 147-154

  13. Sperling, C.; Schweiß, R.; Streller, U.; Werner, C.
    In vitro hemocompatibility of self-assembled monolayers displaying various functional groups more
    Biomaterials 26 (2005) 6547-6557

  14. Sperling, C.; Salchert, K.; Streller, U.; Werner, C.
    Covalently immobilized thrombomodulin inhibits coagulation and complement activation of artificial surfaces in vitro more
    Biomaterials 25 (2004) 5101-5113

  15. Gouzy, M.-F.; Sperling, C.; Salchert, K.; Pompe, T.; Streller, U.; Uhlmann, P.; Rauwolf, C.; Simon, F.; Böhme, F.; Voit, B.; Werner, C.
    In vitro blood compatibility of polymeric biomaterials through covalent immobilization of an amidine derivative more
    Biomaterials 25 (2004) 3493-3501

  16. Streller, U.; Sperling, C.; Hübner, J.; Hanke, R.; Werner, C.
    Design and Evaluation of Novel Blood Incubation Systems for In Vitro Hemocompatibility Assesment of Planar Solid Surfaces more
    Journal of Biomedical Materials Research 66b (2003) 379-390

  17. Salchert, K.; Pompe, T.; Sperling, C.; Werner, C.
    Quantitative analysis of immobilized proteins and protein mixtures by amino acid analysis more
    Journal of Chromatography / A 1005 (2003) 113-122

  18. Pompe, T.; Zschoche, St.; Herold, N.; Salchert, K.; Gouzy, M.-F.; Sperling, C.; Werner, C.
    Maleic Anhydride Copolymers - A Versatile Platform for Molecular Biosurface Engineering more
    Biomacromolecules 4 (2003) 1072-1079

  19. Werner, C.; Pompe, T.; Salchert, K.; Streller, U.; Sperling, C.; Zschoche, St.; Oswald, J.
    Biomimetische Polymerbeschichtungen für innovative Therapien more
    Wissenschaftliche Zeitschrift der Technischen Universität Dresden (2002) 19-23

  20. Gouzy, M.-F.; Sperling, C.; Streller, U.; Salchert, K.; Böhme, F.; Voit, B.; Werner, C.
    Immobilization of small synthetic thrombin inhibitors at the surface of a polymeric biomaterial more
    Polymer Preprints 43 (2002) 695-696

Dr. Claudia Sperling
Dr. Claudia Sperling


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Dr. Claudia Sperling