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Authors
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Harmon, T.S. ; Jülicher, F.
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Title
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Molecular assembly lines in active droplets
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Date
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11.03.2022
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Number
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60601
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Abstract
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Large protein complexes are assembled from protein subunits to form a specific structure. In our theoretic work, we propose that assembly into the correct structure could be reliably achieved through an assembly line with a specific sequence of assembly steps. Using droplet interfaces to position compartment boundaries, we show that an assembly line can be self-organized by active droplets. As a consequence, assembly steps can be arranged spatially so that a specific order of assembly is achieved and incorrect assembly is strongly suppressed.
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Publisher
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Physical Review Letters
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Wikidata
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Citation
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Physical Review Letters 128 (2022) Article Number: 108102
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DOI
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https://doi.org/10.1103/PHYSREVLETT.128.108102
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Tags
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