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Authors
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Chen, X.; Seyboldt, R.; Sommer, J.-U.; Jülicher, F.; Harmon, T. S.
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Title
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Droplet differentiation by a chemical switch
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Date
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29.05.2024
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Number
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0
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Abstract
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A fundamental question about biomolecular condensates is how distinct condensates can emerge from the interplay of different components. Here we present a minimal model of droplet differentiation where phase separated droplets demix into two types with different chemical modifications triggered by enzymatic reactions. We use numerical solutions to Cahn-Hilliard equations with chemical reactions and an effective droplet model to reveal the switchlike behavior. Our work shows how condensate identities in cells could result from competing enzymatic actions.
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Publisher
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American Physical Society
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Wikidata
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Citation
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Physical Review Letters 133 (2024) 028402
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DOI
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https://doi.org/10.1103/PhysRevLett.133.028402
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Tags
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