Authors Millican, J. ; Bittrich, E. ; Caspari, A. ; Pöschel, K. ; Drechsler, A. ; Freudenberg, U. ; Ryan, T. G. ; Thompson, R. L. ; Pospiech, D. ; Hutchings, L.
Title Synthesis and characterisation of a mussel-inspired hydrogel film coating for biosensors
Date 15.06.2021
Number 59384
Abstract Mussel-inspired, catechol-containing monomers are being increasingly utilised to design versatile, adhesive, functional copolymers. This work reports the synthesis and detailed characterisation of a novel terpolymer comprising dopamine methacrylamide (DMA), in order to produce surface coatings capable of acting as biosensors for, e.g., toxins. DMA is copolymerised with 2-hydroxyethyl methacrylate (HEMA) and glycidyl methacrylate (GMA) using free radical polymerisation. The copolymers are subsequently deposited as a thin film using spin-coating. It is demonstrated that a terpolymer comprising HEMA, GMA and DMA can immobilise an IgG antibody on the film surface. The terpolymer therefore has the potential to be used as a coating in biosensing devices. It is also demonstrated that the presence of DMA impacts the copolymer properties. In-situ ellipsometry is used to confirm the important role of the catechol group on copolymer adhesion and significant desorption was observed in the absence of DMA.
Publisher European Polymer Journal
Citation European Polymer Journal 153 (2021) 110503

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