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Authors Zoupi, L. ; Booker, S.A. ; Eigel, D. ; Werner, C. ; Kind, P.C. ; Spires-Jones, T.L. ; Newland, B. ; Williams, A.
Title Selective vulnerability of inhibitory networks in multiple sclerosis
Date 01.02.2021
Number 59194
Abstract In multiple sclerosis (MS), a chronic demyelinating disease of the central nervous system, neurodegeneration is detected early in the disease course and is associated with the long-term disability of patients. Neurodegeneration is linked to both inflammation and demyelination, but its exact cause remains unknown. This gap in knowledge contributes to the current lack of treatments for the neurodegenerative phase of MS. Here we ask if neurodegeneration in MS affects specific neuronal components and if it is the result of demyelination. Neuropathological examination of secondary progressive MS motor cortices revealed a selective vulnerability of inhibitory interneurons in MS. The generation of a rodent model of focal subpial cortical demyelination reproduces this selective neurodegeneration providing a new preclinical model for the study of neuroprotective treatments.
Journal Acta Neuropathologica
Wikidata
Citation Acta Neuropathologica 141 (2021) 415-429
DOI https://doi.org/10.1007/S00401-020-02258-Z

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