Authors Machalowski, T. ; Wysokowski, M. ; Zoltowska-Aksamitowska, S. ; Tsurkan, M. ; et al.,
Title Spider Chitin. The biomimetic potential and applications of Caribena versicolor tubular chitin
Date 15.12.2019
Number 57233
Abstract Diverse fields of modern technology and biomedicine can benefit from the application of ready-to-use chitin-based scaffolds. In this work we show for the first time the applicability of tubular and porous chitin from Caribena versicolor spiders as a scaffold for the development of an effective CuO/Cu(OH)2 catalyst for the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AM), and as a scaffold for the tissue engineering of selected cells. The formation of CuO/Cu(OH)2 phases on and within the chitinous tubes leads to a hybrid material with excellent catalytic performance with respect to the reduction of p-nitrophenol. On the other hand, experimental results provide for the first time strong evidence for the biocompatibility of spider chitin with different cell types, a human progenitor cell line (hPheo1), as well as cardiomyocytes differentiated from induced pluripotent stem cells (iPSC-CMs) that were cultured on a tube-like scaffold.
Publisher Carbohydrate Polymers
Citation Carbohydrate Polymers 226 (2019) 115301

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