Authors Breier, A. ; Schulze-Tanzil, G. ; Meyer, M. ; Rentsch, B. ; Hoyer, M. ; Rentsch, C. ; Schröpfer, M. ; Hahn, J. ; Spickenheuer, A. ; Heinrich, G.
Title Tissue Engineering einer vorderen Kreuzbandplastik auf der Basis resorbierbarer, gestickter Träger. Teil II: Biofunktionalisierung und Tissue Engineering des triphasischen Konstrukts
Date 01.03.2019
Number 56441
Abstract The replacement of the anterior cruciate ligament (ACL) by a tissue engineered substitute could be the favored surgical practice in future superseding the transplantation of autologous tendons with limited availability. An essential requirement for the application is a sufficient biomechanical resistance as well as an adequate bio-functionality of the surrogate structure. A scaffolding structure was developed using embroidery technology, performing the mechanical challenges of the three tissue domains ligament, enthesis and bone in a joint venture project funded by the Deutsche Forschungsgemeinschaft (DFG) (PAK731). Bio-functionality was enhanced by modification of the thread surface through fluorination and collagen coating. Tissue engineering was tested in vitro with different cell types in a spheroid based cultivation under various conditions. The first part of this article described the design of the scaffold structure and the biomechanical adaption [1], the second part shows results from the biological and tissue engineering approaches.
Journal GAK : Gummi Fasern Kunststoffe
Citation GAK : Gummi Fasern Kunststoffe 72 (2019) 110-117

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