Authors Müller, C. ; Ansorge, M. ; Espig, M. ; Zschoche, St. ; Schiller, J. ; Pompe, T.
Title Covalent binding of maleic anhydride copolymer monolayers to polyacrylamide hydrogels
Date 05.09.2018
Abstract Physicochemical surface modifications of soft hydrogel layers are beneficial tools for modulating biomimetic substrate properties in cell adhesion studies. Recently, a layered system of a polyacrylamide hydrogel with a monolayer coating of maleic anhydride copolymers was introduced, however, without a detailed study of the chemical coupling mechanism. Herein it is shown that a stable coupling results from covalent binding of maleic anhydride residues to the primary amides of polyacrylamide via imide bond formation. The many anhydride moieties of the copolymer chains allow for coupling with a low–yield reaction at mild conditions. Furthermore, hydrogen bonding and polar interactions are excluded to account for a stable binding of maleic anhydride copolymers to polyacrylamide hydrogels.
Journal Macromolecular Chemistry and Physics 219 (2018) ID1800206

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