Authors Racovita, S. ; Vasiliu, A.-L. ; Bele, A. ; Schwarz, D. ; Steinbach, C. ; Boldt, R. ; Schwarz, S. ; Mihai, M.
Title Complex calcium carbonate/polymer microparticles as carriers for aminoglycoside antibiotics
Date 27.06.2018
Number 55505
Abstract Composite microparticles of CaCO3 and two pectin samples (which differ by the functional group ratio) or corresponding nonstoichiometric polyelectrolyte complexes with different molar ratios (0.5, 0.9 and 1.2) are obtained, characterized and tested for loading and release of streptomycin and kanamycin sulphate. The synthesized carriers were characterized before and after drug loading in terms of morphology (by SEM using secondary electron and energy selective backscattered electron detectors), porosity (by water sorption isotherms) and elemental composition (by elemental mapping using energy dispersive X-ray and FTIR spectroscopy). The kinetics of the release mechanism from the microparticles was investigated using Higuchi and Korsmeyer–Peppas mathematical models.
Journal RSC Advances
Citation RSC Advances 8 (2018) 23274-23283

Back to list