Authors Franiak-Pietryga, I. ; Maciejewski, H. ; Ziemba, B. ; Appelhans, D. ; Voit, B. ; Misiewicz, M. ; Robak, T. ; Trelinski, J. ; Bryszewska, M. ; Borowiec, M.
Title Blockage of Wnt/B-catenin signaling by nanoparticles reduces survival and proliferation of CLL cells in vitro
Date 31.12.2015
Number 53425
Abstract The Wnt pathway is critical for the proliferation and cell fate determination of many cell types, including B cells of chronic lymphocytic leukemia (CLL). Wnt proteins act on target cells by binding to the Frizzled (Fz)/low-density lipoprotein (LRP) complex at the cell membrane. In the hematopoietic system, Wnt/ß-catenin signaling pathway has been shown to be important in the control of the survival, proliferation and differentiation of hematopoietic cells.<br />Nanotechnology, a new and promising field, may be of use in medicine and the pharmaceutical industry. Dendrimers are nanoparticles of dendritic architecture. We have already proved the influence of PPI-G4-OS-M3 dendrimers in cultures in vitro on CLL cells apoptosis. CLL lymphocytes are characterized by the failure in the apoptosis pathway, but it is also proved that they manifest increased proliferation.<br />Herein, the objective was to evaluate how MEC-1 cells survival and proliferation in vitro is affected by blockage of Wnt pathway by PPI-G4-OS-M3 dendrimer comparing to FA.
Publisher Blood
Citation Blood 126 (2015) ID3699

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