|Authors||Sakiyama-Elbert, S. E. ; Werner, C.|
Drug delivery via heparin conjugates [4.25]
Comprehensive Biomaterials II , Saleem Hashmi, ed.
|Abstract||Affinity-based drug delivery systems provide a simple and gentle method of drug delivery for protein drugs, such as growth factors because they can be sequestered in their native form. Many growth factors bind to heparin with moderate to high affinity making it ideal for use as a potential binding site. Heparin-binding delivery systems have been developed with both covalent and non-covalent heparin immobilization that provide controlled delivery of growth factors for many applications in regenerative medicine including angiogenesis, cutaneous wound healing and peripheral nerve injury. These heparin immobilization methods can be used with many different types of biomaterial scaffolds including hydrogels from natural and synthetic materials as well as degradable polyesters, such as poly(lactic-co-glycolic acid), making heparin conjugation a very versatile approach for growth factor delivery. This chapter outlines the rationale for using heparin conjugates, various methods for heparin immobilization, example of applications of heparin-based delivery systems and heparin mimetic approaches to drug delivery. <br />Comprehensive Biomaterials II : Volume 4: Biocompatibility, Surface Engineering, and Delivery of Drugs, Genes and Other Molecules<br />ISBN 978-0-12-803581-8|
|Citation||Elsevier 4 (2017) 464-471|