Authors Paolino, M. ; Komber, H. ; Mennuni, L. ; Caselli, G. ; Appelhans, D. ; Voit, B. ; Cappelli, A.
Title Supramolecular glycodendrimer-based hybrid drugs
Date 16.10.2014
Number 43982
Abstract Specific non-covalent interactions are commonly used by nature to modulate numerous processes including cell recognition, virus’s adhesion and transmembrane communications. Here we report on the design, synthesis, and preliminary characterization of new supramolecular glycodendrimers-based hybrid drugs based on adamantyl-modified glycodendrimers of third, fourth or fifth generation (mPPI-G3-AdaB, mPPI-G4-AdaB and mPPI-G5-AdaB) and a new heterobifunctional ligand. This component was tailored to bind through non-covalent interactions both the multimeric natural 5-HT3 receptor (through an optimized arylpiperazine pharmacophore) and the adamantyl groups located on the glycodendrimer surfaces (through a ß-cyclodextrin residue) giving rise to biorelevant supramolecular constructs.
Publisher Biomacromolecules
Citation Biomacromolecules 15 (2014) 3985–3993
Tags poly(propylene imine) glycodendrimers 5-ht3 receptor dendrimers chemistry polymers cyclodextrin molecules antagonists toxicity ligands

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