Authors Striegler, C. ; Schumacher, M. ; Effenberg, C. ; Müller, M. ; Seckinger, A. ; Hose, D. ; Voit, B. ; Gelinsky, M. ; Appelhans, D.
Title Dendritic glycopolymer as drug delivery system for proteasome inhibitor bortezomib in a calcium phosphate bone cement: First steps toward a local therapy of osteolytic bone lesions
Date 28.05.2015
Number 42522
Abstract Establishment of drug delivery system (DDS) in bone substitute materials for local treatment of bone defects still requires ambitious solutions for a retarded drug release. We present two novel DDS, a weakly cationic dendritic glycopolymer and a cationic polyelectrolyte complex, composed of dendritic glycopolymer and cellulose sulfate, for the proteasome inhibitor bortezomib. Both DDS are able to induce short-term retarded release of bortezomib from calcium phosphate bone cement in comparison to a burst-release of the drug from bone cement alone. Different release parameters have been evaluated to get a first insight into the release mechanism from bone cements. In addition, biocompatibility of the calcium phosphate cement, modified with the new DDS was investigated using human mesenchymal stromal cells.
Publisher Macromolecular Bioscience
Wikidata Q53675025
Citation Macromolecular Bioscience 15 (2015) 1283-1295
Tags calcium phosphate bone cement dendritic glycopolymer drug release polyelectrolyte complex poly(propylene imine) dendrimers diagnosed multiple-myeloma differentiation in-vitro hyperbranched polymers branching motifs om-peis nanoparticles glycodendrimers ar

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